帕金森病抑郁的发生率及相关因素分析

The incidence and the related factors of the depression in Parkinson′s disease

目的:探讨帕金森病抑郁的发生率及相关因素。方法:收集52例原发性帕金森病患者相关资料,完善汉密尔顿抑郁量表-24项、帕金森病非运动症状评定量表、帕金森病生活质量调查表-39、统一帕金森评分量表、修订的Hoehn-Yahr分级量表、修订的Schwab和英格兰日常生活活动量表、简明心理状态量表等,得出本研究中帕金森病抑郁的发生率,经Spearman相关分析其相关因素。结果:帕金森病合并抑郁者36例,占69.23%;其中简明心理状态量表评分(r=-0.294,P=0.036)及Schwab和英格兰日常生活活动量表评分(r=-0.506,P<0.001)与抑郁严重程度呈负相关,病程(r=0.274,P=0.049)、统一帕金森评分量表评分(r=0.485,P<0.001)、Hoehn-Yahr分级量表评分(r=0.459,P=0.001)、非运动症状评定量表评分(r=0.729,P<0.001)及生活质量调查表-39评分(r=0.619,P<0.001)与抑郁严重程度呈正相关。结论:帕金森病抑郁的发生率较高,与之相关的因素较多,并影响患者日常生活质量。

Objective To investigate the incidence and the related factors of the depression in Parkinson＇s disease. Methods 52 cases with idiopathic Parkinson＇s disease were included in this study. Such scales as Hamilton depression scale-24 item （HAMD-24）, Non Motor Symptoms Scale for Parkinson＇s disease （NMSS）, 39-item Parkinson＇s Disease Questionnaire （PDQ-39）, unified Parkinson＇s disease rating scale （UPDRS）, revised Hoehn-Yabr rating scale （H-Y）, revised Schwab and English daily life event scale （S-E）, Minimum Mental State Examination （MMSE）, etc. were applied and underwent Spearman correlation analysis. Results Thirty-six patients with Parkinson＇s disease （69.23%） met the criteria for depression. The spearman rank correlation analysis showed that MMSE （r = -0.294, P= 0.036） and S-E （r = -0.506, P〈 0.001） had negative correlation with depression in Parkinson＇s disease, and the course of the disease （r = 0.274, P = 0.049）, UPDRS （r = 0.485, P 〈 0.001）, H-Y （r = 0.459, P = 0.001）, NMSE （r = 0.729, P 〈 0.001） and PDQ-39 （r = 0.619, P 〈 0.001） had positive correlation with depression in Parkinson＇s disease. Conclusions The patients with Parkinson＇s disease had high incidence of depression. The depression in Parkinson＇s disease is associated with many factors and affected the quality of life of the patients.