ABI1表达上调与结直肠腺癌临床病理及预后的相关性分析

The relationship between ABI1 upregulation and clinicopathological features and prognosis of colorectal adenocarcinoma

目的分析Abl相互作用蛋白1（Ab1 interactor 1，ABI1）表达与结直肠腺癌临床病理特征和预后的相关性。方法应用免疫组织化学技术，检测ABI1蛋白在218例结直肠腺癌组织中的表达，利用矿检验及Spearman相关检验，分析ABI1表达与结直肠腺癌临床病理特点的相关性[χ^2和（或）Fisher检验及Spearman相关检验]，应用Kaplan-Meier方法计算其中109例结直肠腺癌患者术后5年生存率及生存时间。结果相对于癌旁组织，ABI1在结直肠腺癌中的表达明显上调（P=0．000）；ABI1表达与结直肠腺癌浸润深度（P=0．040）和组织分化程度（P=0．043）显著相关，而与肿瘤部位、临床分期、淋巴结和远处转移等无相关性；高表达和低表达ABI1的患者术后5年累积生存率分别为45．6％和76．9％，中位生存时间为71．6（95％CI：57．4—85．7）个月和99．0（95％CI：85．6—112．4）个月，Kaplan—Meier分析显示，差异有统计学意义（r=11．090，P=0．001）。多因素分析显示，ABI1不是一个独立的结直肠癌预后评估因素（P=0．119）。结论结直肠腺癌组织中表达的显著上调提示ABI1具有潜在的促癌作用；ABI1表达上调与结直肠腺癌的浸润程度、组织分化程度和患者生存时间相关。

Objective To analyze the correlation between the expression of Abl interactor 1 （ ABI1 ） and the clinicopathologic characteristics in colorectal adenocarcinoma tissues. Methods Immunohistochemistry was used to determine ABI1 expression in human colorectal adenocarcinoma tissues and matched adjacent tissues. A statistical analysis was used to determine the potential correlation between ABI1 expression and clinicopathological characteristics and prognosis. Results ABI1 is up-regulated in colorectal adenocarcinoma tissues compared with matched adjacent tissues （P = 0. 000）, ABI1 expression is significantly correlated with infiltration （ P = 0. 043 ） and differentiation （ P = 0. 040）, but not with sex, age, tumor location, clinical stage, lymph node metastasis and distant metastasis （ P 〉 0. 05） ; It was also shown that ABI1 expression had a significant influence on prognosis （χ^2= 11. 090, P = 0. 001 ）. Multivariate analyses showed that high ABI1 expression is not an independent poor prognostic factor for overall survival （P = 0. 119）. Conclusion ABI1 overexpression might act as pro-oncogene for patients with colorectal adenocarcinoma.