聚胺类功能性2,4-滴制剂的制备与控释性能评价

Preparation of 2,4-D Polyamines and Their Controlled Release Property

[目的]提高2,4-滴等有机酸类农药的有效利用率。[方法]使用聚N,N-二甲基乙烯基胺、聚N,N-二甲基烯丙基胺、甲基化聚乙烯亚胺(PEI)、聚脒等4种聚胺类功能性高分子与2,4-滴结合形成水溶性制剂,并测试其对2,4-滴透析释放情况的影响。[结果]水中透析以甲基化PEI、聚N,N-二甲基烯丙基胺、聚N,N-二甲基乙烯基胺的控释能力为佳。叔胺度69.0%的甲基化PEI质量≥42.6%时,释放率在32%左右达到控释平衡,且药剂释放比较集中。[结论]聚胺类高分子与2,4-滴的结合可以改善2,4-滴的控释性能。

[Aims] In order to improve the effective utilization of organic acid pesticides such as 2,4-D. [Methods] Watersoluble preparations of 2,4-D with four functional polyamines were prepared. Functional polyamines were synthesized by further methylation ofvariety ofpolyamines such as poly （N,N-dimethylethylene amine）, poly （N,V-dimethylallylamine） and polyethyleneimine （PEI）. In addition, their controlled release behaviorwas tested. [Results] The preparations with methylated PEI, poly （N,N-dimethylethylene amine）, poly （N,N-dimethylallylamine） exhibited good controlled-release capability. As the content of methylated PEI with tertiary amine of 69.0% more than 42.6%, it achieved the balance with the release rate of 32%, in addition, the release of the drug was concentrated. [Conclusions] Water-soluble preparations of 2,4-D with four functional polyamines can improve the controlled release properties of 2,4-D.