24%螺螨酯·阿维菌素悬浮剂的制备及表征

Preparation and Characterization of Spirodiclofen·Abamectin 24% SC

[目的]制备24%螺螨酯·阿维菌素悬浮剂并对其性能进行表征。[方法]共毒系数法确定最佳复配比例;单因素优选法筛选助剂并结合正交试验优化得到最佳配方。[结果]螺螨酯和阿维菌素的最佳配比为23∶1;最佳配方:螺螨酯原药23.2%、阿维菌素原药1.1%、D305 7%、硅酸镁铝0.8%、丙三醇6%、消泡剂CF580 0.3%,蒸馏水补足100%。最佳加工工艺:制剂质量为10 g时,锆珠(d=1.2 mm)用量为17 m L,即锆珠体积是制剂质量的1.7倍,研磨时间为2.5 h。[结论]制备的产品各项指标均符合悬浮剂国家标准。

[Aims] The forrnula of spirodiclofen, abamectin 24% SC was prepared, and the performance was investigated. [Methods] The optimal mixing-ratio was determined by the co-toxicity coefficient method. The best formula was determined by single-factor test and orthogonal experiment. [Results] The optimal mixing-ratio of spirodiclofen and abamectin was 23：1. The best formula was spirodiclofen TC 23.2%, abamectin TC 1.1%, D305 7%, magnesium aluminium silicate 0.8%, glycerin 6%, defoaming agent of CF580 0.3%, and distilled water making up to 100%. The optimal process was the volume of zirconium bead （d=1.2mm） was 17 mL for 10 g of formulation, and the milling time was 2.5 h. [Conclusions] All specifications of the formulation meet the national standards for suspension concentrate.