基于拟氨基酸多重集的DNA序列的数值刻画及其应用

Numerical characterization of DNA sequences based on multisets of pseudo amino acids and its applications

利用密码子与氨基酸及终止信号之间的映射关系,提出了DNA序列的拟氨基酸序列。然后,借助多重集,构造了DNA序列的21维的数值向量表示,据此可计算DNA序列之间的相似距离。通过对汉坦病毒S片段全基因序列、番茄黄化曲叶病毒全基因组序列以及人鼻病毒全基因组序列3个数据集的系统发育分析,证明了所提方法的有效性。

According to a mapping of codons and amino acids and stop signal, the sequence of pseudo amino acid for DNA sequence was proposed. Then, by means of the muhiset, a 21-dimensional numerical vector of a DNA se- quence was constructed. On the basis of the vector, the similarity distance between any two DNA sequences can be calculated. The phylogenetic analysis on three datasets （ S segment of hantaviruses, complete genome sequences of Tomato yellow leaf curl virus and complete genome sequences of human rhinovirus） demonstrated the effectiveness of the proposed method.