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组蛋白去乙酰化酶抑制剂抗肿瘤的机制研究和临床应用

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摘要 组蛋白去乙酰化酶能通过改变组蛋白乙酰化的水平,使得染色体结构重塑,影响基因的表达。在人类肿瘤中,组蛋白去乙酰化酶出现了表达及活性的异常,同时存在着被异常招募。组蛋白去乙酰化酶抑制剂的研究进展显示了其在肿瘤治疗中的巨大潜能。文章就组蛋白酶去乙酰化酶抑制剂在肿瘤治疗中的进展作一综述。
作者 司林华
出处 《西藏科技》 2015年第7期40-42,共3页 Xizang Science And Technology
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