羟考酮联合氟比洛芬酯用于骨科术后镇痛中的效果研究

Effect of postoperative analgesia in orthopedic oxycodone for joint flurbiprofen

目的:分析羟考酮联合氟比洛芬酯用于骨科术后镇痛中的临床疗效与安全性,为骨科手术镇痛提供临床研究。方法:选择2013年4月至2014年5月期间行骨科手术的80例患者,按照采用的镇痛方法将其分为对照组和实验组,每组40例,实验组患者术后连接羟考酮联合氟比洛芬酯配镇痛泵进行镇痛(盐酸羟考酮50 mg+氟比洛芬酯250 mg+生理盐水至100 m L),对照组患者术后连接地佐辛联合氟比洛芬进行镇痛(地佐辛25 mg+氟比洛芬酯250 mg+生理盐水至100 m L)。观察两组患者术后镇痛的VAS、BCS与Ramsay评分的差异性;分析两组患者总体满意度的差别;比较两组患者术后镇静不良反应的状况。结果:实验组术后镇静1 h、3 h、5 h、7 h的VAS、BCS评分明显高于对照组,组间比较差异均有统计学意义(P<0.05),术后12 h、24 h以及48 h的VAS、BCS评分和对照组比较差异无统计学意义(P>0.05);实验组患者术后1 h、3 h、5 h、7 h、12 h、24 h以及48 h的Ramsay评分与对照组比较差异无统计学意义(P>0.05);实验组患者I级、II级满意率高于对照组患者(P<0.05),III级、IV级满意率低于对照组患者(P<0.05);两组患者术后镇静发生的头晕、恶心、呕吐、皮肤瘙痒、呼吸异常、以及其他不良反应发生率比较差异无统计学意义(P>0.05)。结论:羟考酮联合氟比洛芬酯用于骨科术后镇痛,能够明显改善患者的VAS、BCS评分,显著提高患者镇痛总体满意度,安全可靠,是一种值得在临床上推广使用的骨科术后镇痛方法。

Objective：To analyze the oxycodone combined flurbiprofen for postoperative analgesia in orthopedic clinical efficacy and safety in clinical studies to provide analgesia for orthopedic surgery. Methods：From April 2013 to May 2014 during orthopedic sur-gery,80 patients,according to the analgesic method used will be divided into a control group and the experimental group,40 cases,each group of patients in the experimental group connected oxycodone ketone combined with flurbiprofen analgesia analgesia （ oxycodone hydrochloride 50mg＋250mg＋saline flurbiprofen to 100 mL）,patients in the control group connected Dezocine joint flurbiprofen anal-gesia（Dezocine flurbiprofen 25 mg＋250mg＋saline to 100mL）. Were observed in patients with postoperative pain VAS,BCS and Ram-say score differences;analyze the differences in the two groups of patients overall satisfaction;relatively poor condition of postoperative sedation reactions. Results：The experimental group were killed 1h,3h,5h,VAS 7h time,BCS score significantly higher,the difference was statistically significant（P〈0. 05）between the two groups,after 12h,24h and 48h,VAS,BCS score and the control group showed no significant difference（P〉0. 05）;patients in the experimental group 1h,3h,5h,7h,12h,Ramsay score difference compared with the control group,24h and 48h,no significant（P〉0. 05）;the experimental group were grade I,II level patient satisfaction rate was higher （P〈0. 05）,III level,IV-class patient satisfaction rate than the control group（P〈0. 05）;The postoperative sedation dizziness occur,nausea,vomiting,pruritus, respiratory disorders, as well as the incidence of other adverse events was no significant difference （ P 〉0. 05）. Conclusion：Oxycodone joint flurbiprofen for orthopedic postoperative analgesia,can significantly improve the patient’s VAS, BCS score significantly improve patients’ overall satisfaction with analgesia,safe and reliable,is a worthy use in clinical practice orthope-dic postoperative analgesia.