复方三七散外敷防治静脉留置针所致静脉炎的效果

Effect of Fufang Sanqi Powder on the Prevention of Phlebitis Caused by Venous Indwelling Needle

目的探讨复方三七散防治静脉留置针所致静脉炎的效果,以期为临床推广应用提供依据。方法 2014年,选取成年新西兰大耳兔48只,按随机数字表法将其分为3组,分别为对照组、硫酸镁组和复方三七散组,每组16只。3组兔子耳外缘静脉血管穿刺后留置静脉留置针,每天注射生理盐水20ml。对照组不用任何药物,硫酸镁组给予50%硫酸镁纱布湿敷,复方三七散组给予复方三七散药粉和70%乙醇混合药糊外敷,换药1次/d,连续观察10d。分别在第4、6、8、10天各处死4只兔子,取外耳缘静脉标本进行肉眼观察和病理学观察。结果肉眼观察显示,在第4天和第6天肉眼观察各组均无静脉炎出现,第8天和第10天复方三七散组静脉炎发生率小于对照组(均P<0.05),第10天复方三七散组静脉炎发生率小于硫酸镁组(P<0.05)。病理学观察显示,在第8、10天三组兔子的炎症反应的差异有统计学意义(P<0.05);血栓形成情况显示,在第4、6、8天各组兔子血栓形成的差异无统计学意义,在第10天复方三七散组血栓形成少于其他两组(P<0.05)。结论复方三七散外敷具有防治静脉留置针所致静脉炎的作用,且效果优于硫酸镁。

Objective To investigate the effect of Fufang Sanqi powder for prevention of phlebitis caused by venous in- dwelling needle,in order to provide theoretical basis for clinical applications.Methods Totally 48 adult New Zealand rabbits were randomly divided into control group, Magnesium sulfate group and Fufang Sanqi group, with 16 rabbits in each group.Each rabbit was handled with intravenous indwelling needle in was given no ear margin vein puncture,and was injected physiological saline 20ml daily.The control group without any drug,and Magnesium sulfate group was given 50 % Magnesium sulfate gauze hydropathic compress,Fufang Sanqi powder group was given Fufang Sanqi pow- der and 70 % alcohol mixed medicine paste for external application, change it once every day, with continuous observa- tion of 10 days.4 rabbits were killed at the 4th, 6th,8th, 10th day respectively, the ear marginal veins were observed by naked eye observation and pathology.Results The naked eye observation showed that there was no phlebitis occurred in every group at 4th day and 6th day.At the 8th day the incidence of phlebitis in Fufang Sanqi powder group was less than that of the control group （all P〈0.05）.At 10th day,the incidence of phlebitis in Fufang Sanqi powder group was less than that of Magnesium sulfate group （P〈0.05）.Pathological observation showed that the incidence of inflamma- tory reaction of 8th, 10th day in Fufang Sanqi powder group was less than that of the control group （P〈0.05）.Regard- ing to the thrombosis,there was no significant difference among three groups at 4th,6th and 8th day,while at the 10th day,the rate of Fufang Sanqi powder group was less than the other two groups （P〈0.05）.Conclusion Fufang Sanqi powder can prevent phlebitis caused by venous indwelling needle and the effect is better than Magnesium sulfate.