病毒感染与川崎病的相关性探讨

Correlation between Kawasaki disease and virus infection

目的探究病毒感染与川崎病的相关性。方法选取川崎病患儿35例为观察组,同期选取发热性疾病但非川崎病患儿35例为对照组。对两组患儿的病毒感染情况进行比较,并行超声心动图检查,比较两组患儿冠脉损伤情况。结果两组患儿共病毒感染29例,其中,观察组感染18例,对照组感染11例,分别为EB病毒、单纯疱疹病毒、冠状病毒、呼吸道合胞病毒、副流感病毒,其中,观察组患儿EB病毒感染明显多于对照组患儿,差异具有统计学意义(P<0.05),单纯疱疹病毒、冠状病毒、呼吸道合胞病毒、副流感病毒,比较差异均无统计学差异(P>0.05);将病毒感染组与未感染组冠脉损伤情况进行比较,结果显示,感染组患儿冠脉损伤发生率为31.03%,未感染组为4.88%,感染组明显高于未感染组,差异具有统计学意义(P<0.05)。结论川崎病的发生可能与EB病毒感染有关,病毒感染后冠脉损伤的发生增加。

Objective To explore the correlation between virus infection and Kawasaki disease. Methods This study selected 35 children with Kawasaki disease as the observation and 35 children with febrile diseases （ not Kawasaki） as the control group. Their virus infection and coronary artery injury were compared by ultrasonic cadio- gram. Results There were a total of 29 cases of virus infection in the two groups, including 18 cases in the observation group and 11 cases in the control group, causing by EB virus, herpes simplex virus, coronavirus, respiratory syneytial virus, and parainfluenza virus. The children with EB virus infection was more in the observation group than in the control group （ P 〈 0. 05 ）, but there was no significant difference in herpes simplex virus, coronavirus, respiratory syncytial virus and parainfluenza virus between the two groups （ P 〉0. 05 ）. The incidence of coronary artery injury was 31.03% in the infection group, and 4. 88% in the non-infection group respectively （P 〈0. 05）. Condusion Kawasaki disease may be related with EB virus infection, which increases the incidence of coronary artery injury.