D-二聚体和成人社区获得性肺炎严重程度相关性分析被引量：8

Analysis of the association between D-dimer level and the severity of community-acquired pneumonia

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摘要目的：探讨 D-二聚体和成人社区获得性肺炎（CAP）严重程度的相关性。方法回顾性分析安徽医科大学第二附属医院呼吸科2011年1月~2015年4月收治102例成人 CAP 住院患者不同危险分组中D-二聚体变化情况及肺炎累及范围、有无合并胸腔积液对 D-二聚体的影响,观察不同组间的差异。按 CURB-65标准将102例患者分为低危组、中危组和高危组。结果低、中、高危 CAP 患者 D-二聚体异常率分别为62．1%（36/58）和100%（22/22）、95．4%（21/22）。中、高危组 CAP 患者 D-二聚体测定值分别为（3．007±0．329） ug/ ml、（5．404±1．394） ug/ ml,均显著高于低危组（1．068±0．134） ug/ ml、,差异均具有统计学意义（P〈0．05）,D-二聚体与肺炎严重程度存在等级相关性。多肺叶 CAP 患者 D-二聚体水平（3．235±0．528） ug/ ml较单肺叶（0．992±0．167） ug/ ml 明显增高,差异具有统计学意义（P〈0．05）。肺炎伴类肺炎性胸腔积液患者D-二聚体（3．154±0．501） ug/ ml 较未合并胸腔积液组（0．890±0．151） ug/ ml 显著增高,差异具有统计学意义（P〈0．05）。结论 CAP 患者血浆 D-二聚体显著升高,且与病情严重程度存在相关性,肺炎范围及是否合并胸腔积液影响凝血功能,推测 D-二聚体可能成为重症 CAP 患者良好的预测指标。 Objective To explore the association between the level of D-dimer and the severity of communi-ty-acquired pneumonia （CAP）. Methods A retrospective study was performed by investigating D-dimer in 102 pa-tients with CAP,who were admitted to the Respiratory Medical Department of the Second Affiliated Hospital of Anhui Medical University. According to CURB-65 criteria, all the patients were divided into the low-risk,middle-risk and high-risk groups. Results The abnormal rate of D-dimer was 62. 1% ,100% and 95. 4% respectively in the low-risk,middle-risk and high-risk groups. The serum level of D-dimer in the middle-risk and the high-risk groups were （3. 007±0. 329） ug/ ml and （5. 404±1. 394） ug/ ml,which were both higher than that in the low-risk group （1. 068 0. 134 ug/ ml）（P〈0. 05）. The serum level of D-dimer in muti-lobular CAP was （3. 235±0. 528） ug/ ml, which was higher than that in mono-lobular CAP （0. 992±0. 167 ug/ ml）. The serum level of D-dimer in pneumonia pa-tients with pleural effusion was （3. 154±0. 501） ug/ ml,which was higher than that in pneumonia patients without pleural effusion （0. 890±0. 151 ug/ ml）. Conclusion The level of D-dimer is significantly higher in patients with CAP and its level is positively correlated with severity,which could be a good biomaker to assess the severity of CAP.

作者许知礼杨进陆友金

机构地区安徽医科大学第二附属医院呼吸内科

出处《临床肺科杂志》 2015年第9期1661-1663,共3页 Journal of Clinical Pulmonary Medicine

关键词肺炎 D-二聚体 CURB-65 pneumonia D-dimer CURB-65

分类号 R563.1 [医药卫生—呼吸系统]

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