肺炎支原体肺炎患儿血清白介素17和白介素23表达的意义

Change and significance of serum IL-17 and IL-23 in children with Mycoplasma pneumoniae pneumonia

目的分析并评价肺炎支原体肺炎患儿血清白介素17和白介素23表达情况。方法将我院自2014年1月至2014年7月期间收治的107例肺炎患儿按照肺炎支原体抗体检测情况分为肺炎支原体肺炎组52例(观察组)与其他肺炎组55例(对照组)。全部儿童均进行血清IL-17、IL-23、肺炎支原体抗体、白细胞计数、中性粒细胞、C反应蛋白等进行测定。结果肺炎支原体肺炎组患儿血清IL-17及IL-23含量最高(P均<0.01)。其中,肺炎支原体肺炎组的血清IL-17和IL-23含量均高于其他肺炎组(P均<0.05)。两组的中性粒细胞数与IL-17及IL-23含量均呈正相关(P均<0.05)。结论白介素17和白介素23在肺部肺炎支原体感染过程中参与免疫应答,可能与肺炎支原体清除过程有关。

Objective To analyze the expression of serum IL-17 and ILo23 in children with Mycoplasma pneumoniae pneumonia. Methods 107 children with pneumonia from January to July, 2014 were divided into the observation group and the control group based on the detection of Mycoplasma pneumoniae antibody. Their serum IL- l7, IL-23, Mycoplasma pneumoniae antibody, white cell count, neutrophil and C reactive protein were detected. Resuits The levels of IL-17 and IL-23 were higher in the observation group than in the control group （ P 〈 0.05 ）. The number of neutrophil was positively correlated with the levels of IL-17 and IL-23 （ P 〈 0.05 ）. Conclusion IL-17 and IL-23 involve in immune response of Mycoplasma pneumoniae infection process, which may be related with Myco- plasma pneumoniae clearance.