慢性阻塞性肺疾病患者sRAGE与AGEs水平变化及意义

Changes of sRAGE and AGEs and its significance on patients with chronic obstructive pulmonary disease

目的探讨慢性阻塞性肺疾病患者血浆sRAGE与AGEs水平变化及意义。方法选取我院80例慢阻肺急性加重期患者与80例慢阻肺稳定期患者,分别测量其血浆sRAGE与AGEs浓度。结果慢阻肺急性加重期患者的血浆AGEs浓度明显高于慢阻肺稳定期患者(P<0.01);而血浆sRAGE浓度明显低于稳定期患者(P<0.01);Pearson相关分析结果显示,血浆AGEs浓度与FEV1%呈负相关,血浆sRAGE浓度与FEV1%呈正相关。结论血浆AGEs可能是慢阻肺的危险因素,血浆sRAGE则可能是慢阻肺的保护因素,两者对判断慢阻肺病情严重程度及预后具有一定的应用价值。

Objective To investigate the changes of plasma sRAGE and AGEs and its significance on pa-tients with chronic obstructive pulmonary disease. Methods 80 patients with AECOPD and 80 patients with stable COPD in our hospital were selected, and their plasma sRAGE and AGEs concentration was measured. Results The concentration of plasma AGEs was significantly higher in the AECOPD group than in the stable COPD group, but the concentration of plasma sRAGE was significantly lower in the AECOPD group than in the stable COPD group （P〈0. 01）. Pearson correlation analysis showed that the level of plasma AGEs was negatively correlated with FEV1% , and plasma sRAGE was positively correlated with FEV1% . Conclusion Plasma AGEs may be a risk factor of COPD, and plasma sRAGE a protective factor of COPD, both of which have certain value in the evaluation and prog-nosis of COPD.