慢阻肺患者血清1,25(OH)_2D_3、钙水平与肺功能关系的研究

Relationship of serum 1,25( OH)_2D_3 and calcium levels to lung function of COPD patients

目的分析探讨慢性阻塞性肺疾病急性加重期患者血清1,25-二羟维生素D3[1,25(OH)2D3]、钙(Ca2+)水平与其肺功能关系的相关性。方法选取2013年12月至2014年4月在我院住院的慢阻肺患者60例,分别在其慢阻肺急性加重期和稳定期,抽取静脉血,检测患者血清1,25(OH)2D3、Ca2+、磷(P)的水平,并同时检测其动脉血气分析及肺功能。结果急性加重期的血清1,25(OH)2D3、Ca2+、P以及FEV1/FVC等指标与稳定期相比,明显降低;急性加重期患者血清中1,25(OH)2D3、Ca2+与FEV1(%)呈正相关(r=0.341,0.454,P均<0.01)。结论慢阻肺急性加重期患者的血清1,25(OH)2D3、Ca2+水平与FEV1(%)有相关性,在一定程度上反映了慢阻肺患者疾病严重程度。

Objective To analyze the relationship of serum 1,25 （OH） 2 D3 and calcium levels to lung func-tion of COPD patients. Methods From December 2013 to April 2014, 60 COPD patients were selected in our hospi-tal, and their 1,25 （OH） 2 D3 , P and calcium were detected. At the same time, they were given blood gas analysis and lung function test. Results The levels of 1,25 （OH） 2 D3 , P, calcium and FEV1 / FVC were significant lower in the AECOPD group than in the stable COPD group. The levels of 1,25 （OH） 2 D3 and calcium were positively correla-ted with FEV1 （% ） in AECOPD patients （r = 0. 341, 0. 454, P〈0. 01）. Conclusion In AECOPD patients, the levels of serum 1,25 （OH） 2 D3 and calcium are correlated with FEV1 （% ）, which can reflect the severity of disease at certain extent.