早期补充甲状腺素对早产低出生体质量儿临床康复的影响

Influence of Early Thyroid Hormone Supplementation in Premature and Low Birth Weight Infants on the Clinical Rehabilitation

目的：探讨早产低出生体质量儿早期补充甲状腺素对其临床康复的影响。方法：将喂养困难并确诊为甲状腺功能低下的早产低出生体质量儿37例随机分成治疗组18例和对照组19例。治疗组予口服左旋甲状腺素片10~15μg/（kg·d）替代治疗,对照组与治疗组均常规治疗早产低出生体质量儿并发症（黄疸、新生儿呼吸窘迫综合征、内环境紊乱、胎粪吸入综合征等）。每周复查甲状腺素,两周后观察患儿奶量、体质量、吸吮能力、甲状腺激素等变化。结果：治疗组与对照组相比奶量增加,吸吮能力加强,体质量增加,甲状腺功能恢复明显,差异有统计学意义（P〈0.05）。结论：早产低出生体质量儿早期补充甲状腺素可以早期改善喂养能力,使体质量早日达到正常标准。

Objective： To explore the influence of early thyroid hormone supplementation in premature and low birth weight infants on the clinical rehabilitation. Methods： Thirty-seven infants with feeding difficulties and diagnosed with hypothyroidism in premature and low birth weight were divided into treatment group （ n = 18 ） and control group （ n = 19 ）. The treatment group received L-thyroxine 10 - 15μg/（ kg·d） replacement therapy. The control group and the treatment group were given conventional treatment of complications of premature low birth weight infants （jaundice, neonatal respiratory distress syndrome, internal environmental disorders, meconium inhaled syndrome, etc. ）, a weekly review of thyroid hormone. The changes of milk, weight, sucking ability and thyroid hormone were observed after two weeks. Results： Compared with control group, milk volume increased, sucking capacity strengthed, weight increased, thyroid function recovery in treatment group, there was a significant difference between the two groups （P 〈 0. 05 ）. Conclusion： Thyroid hormone supplements in early premature low birth weight infants can improve early feeding capacity, so that the weight as soon as possible to meet the standards.