儿童毒鼠强中毒浓度与多脏器功能损害的关系

Relationship between Tetramine Toxic Concentration and Multiple Organ Function Damage in Children

目的:探讨儿童毒鼠强中毒浓度与多脏器功能损害的关系。方法:根据临床表现将中毒患儿分为轻度、中度和重度三组,对各组的毒鼠强浓度、肝肾功能、心肌酶和脑电图等资料进行分析。结果:毒鼠强浓度、丙氨酸氨基转移酶和乳酸脱氢酶浓度在轻度组、中度组和重度组比较差异有统计学意义,呈增高趋势(P<0.01),三组中位数(M)和四分位数(P25,P75)分别为0.8(0.3,2.3)、1.8(1.2,4.0)和6.9(2.5,14.8);15(8.7,16.2)、16.0(14.0,24.0)和23.8(19.6,31.0);261.3(194.4,267.0)、228.1(216.4,245.1)和334.0(325.0,356.9)。肌酸激酶同工酶、天门冬氨酸氨基转移酶浓度三组比较差异无统计学意义,但呈增高趋势(P<0.05);三组肌酸激酶比较差异无统计学意义,但普遍异常;三组肌酐和尿素氮比较差异无统计学意义。脑电图异常三组分别为1例(25.0%)、5例(62.5%)和7例(70.0%)。结论:毒鼠强浓度与肝功能、心肌酶和脑电图的损害程度密切相关,是判断中毒程度的一项重要指标。

Objective： To explore the relationship between tetramine toxic concentration and multiple organ function damage in children. Methods： All Children were divided into mild group, moderate group and severe group according to clinical manifestations. For each group, tetramine concentration, liver and kidney function, myocardial enzymes and EEG data were analyzed. Results： The tetramine concentration,ALT and LDH showed an increase trend in the three groups （P〈0.01）. The median and quartile were 0.8 （0.3,2.3）, 1.8 （1.2, 4.0） and6.9 （2.5, 14.8）, 15 （8.7, 16.2）, 16.0 （14.0, 24.0） and23.8 （19.6, 31.0）, 261.3 （194.4, 267.0）, 228. 1 （216.4, 245. 1 ） and 334.0 （325.0, 356.9） in three groups. CK-MB and AST have no significant difference, hut showed an increasing trend （P〈0.05）. There were no significant difference in levels of CK, Cr and BUN, but the level of CK was generally abnormal. EEG abnormalities in the three groups were 1 cases （ 25.0% ）, 5 cases （ 62.5% ） and 7 cases （70.0%）. Conclusion： Liver function, myocardial enzymes and the damage of EEG were positively correlated to tetramine concentration, and tetramine concentration is an important indicator of poisoning degree.