摘要
AIM: To identify the features of early signet ring cell gastric carcinoma using magnification endoscopy with narrow band imaging(NBI).METHODS: A retrospective review was conducted of 12 cases of early signet ring cell gastric carcinoma who underwent treatment in a single institution between January 2009 and April 2013. All patients had magnification endoscopy with NBI and indigo carmine contrast to closely examine the mucosal architecture, including the microvasculature and arrangement of gastric pits. Histologic examination of the final endoscopic submucosal dissection or gastrectomy specimen was performed and compared with the endoscopic findings to identify patterns specific to signet ring cell carcinoma.RESULTS: Twelve patients with early signet ring cell gastric carcinoma were identified; 75% were male, and average age was 61 years. Most of the lesions were stage T1a(83%), while the remainder were T1b(17%). The mean lesion size was 1.4 cm2. On standard endoscopy, all 12 patients had a pale, flat lesion without any evidence of mucosal abnormality such as ulceration, elevation, or depression. On magnification endoscopywith NBI, all of the patients had irregularities in the glands and microvasculature consistent with early gastric cancer. In addition, all 12 patients exhibited the "stretch sign", an elongation or expansion of the architectural structure. Histologic examination of the resected specimens demonstrated an expanded and edematous mucosal layer infiltrated with tumor cells.CONCLUSION: The "stretch sign" appears to be specific for signet ring cell carcinoma and may aid in the early diagnosis and treatment of this aggressive pathology.
AIM： To identify the features of early signet ring cellgastric carcinoma using magnification endoscopy withnarrow band imaging （NBI）.METHODS： A retrospective review was conductedof 12 cases of early signet ring cell gastric carcinomawho underwent treatment in a single institution betweenJanuary 2009 and April 2013. All patients hadmagnification endoscopy with NBI and indigo carminecontrast to closely examine the mucosal architecture,including the microvasculature and arrangement ofgastric pits. Histologic examination of the final endoscopicsubmucosal dissection or gastrectomy specimen wasperformed and compared with the endoscopic findingsto identify patterns specific to signet ring cell carcinoma.RESULTS： Twelve patients with early signet ring cellgastric carcinoma were identified; 75% were male,and average age was 61 years. Most of the lesionswere stage T1a （83%）, while the remainder were T1b（17%）. The mean lesion size was 1.4 cm2. On standardendoscopy, all 12 patients had a pale, flat lesion withoutany evidence of mucosal abnormality such as ulceration,elevation, or depression. On magnification endoscopywith NBI, all of the patients had irregularities in theglands and microvasculature consistent with earlygastric cancer. In addition, all 12 patients exhibitedthe “stretch sign”, an elongation or expansion of thearchitectural structure. Histologic examination of theresected specimens demonstrated an expanded andedematous mucosal layer infiltrated with tumor cells.CONCLUSION： The “stretch sign” appears to bespecific for signet ring cell carcinoma and may aid inthe early diagnosis and treatment of this aggressivepathology.
