摘要
AIM: To define the normal range of liver stiffness(LS) values using transient elastography in living-related liver transplantation candidate donors with normal liver histology. METHODS: LS was measured using Fibroscan in 50(16 women, 34 men) healthy potential donors(mean age 28.4 ± 5.9 years) who were being evaluated for liver donation for their relatives at the National Liver Institute, Menoufeya University, Egypt. All potential donors had normal liver tests and were negative for hepatitis B or C virus infection. Abdominal ultrasounds showed normal findings. None of the subjects had diabetes, hypertension, renal impairment, heart disease, or body mass index > 30 kg/m2. All subjects had normal liver histology upon liver biopsy. They all donated the right lobe of their liver with successful outcomes.RESULTS: The mean LS was 4.3 ± 1.2 k Pa(range: 1.8-7.1 k Pa). The 5th and 95 th percentiles of normal LS were 2.6 k Pa and 6.8 k Pa, respectively, with a median of 4 k Pa; the interquartile range was 0.6 ± 0.4. LS measurements were not significantly different between men and women(4.4 ± 1.1 k Pa vs 3.9 ± 1.3 k Pa) and did not correlate with age. However, stiffness values were significantly lower in subjects with a body mass index < 26 kg/m2 compared to those with an index ≥ 26 kg/m2(4.0 ± 1.1 k Pa vs 4.6 ± 1.2 k Pa; P <0.05). There were no differences in hospital stay or postoperative bilirubin, albumin,alanine and aspartate transaminases, or creatinine levels(at discharge) between donors with livers stiffness ≤ 4 k Pa and those with stiffness > 4 k Pa. CONCLUSION: Healthy donors with normal liver histology have a median LS of 4 k Pa. Stiffness values are elevated relative to increase in body mass index.
AIM To define the normal range of liver stiffness （LS）values using transient elastography in living-relatedliver transplantation candidate donors with normal liverhistology.METHODS： LS was measured using Fibroscan in 50 （16women, 34 men） healthy potential donors （mean age28.4 ± 5.9 years） who were being evaluated for liverdonation for their relatives at the National Liver Institute,Menoufeya University, Egypt. All potential donors hadnormal liver tests and were negative for hepatitis Bor C virus infection. Abdominal ultrasounds showednormal findings. None of the subjects had diabetes,hypertension, renal impairment, heart disease, or bodymass index 〉 30 kg/m2. All subjects had normal liverhistology upon liver biopsy. They all donated the rightlobe of their liver with successful outcomes.RESULTS： The mean LS was 4.3 ± 1.2 kPa （range：1.8-7.1 kPa）. The 5th and 95th percentiles of normal LSwere 2.6 kPa and 6.8 kPa, respectively, with a medianof 4 kPa; the interquartile range was 0.6 ± 0.4. LSmeasurements were not significantly different betweenmen and women （4.4 ± 1.1 kPa vs 3.9 ± 1.3 kPa） anddid not correlate with age. However, stiffness valueswere significantly lower in subjects with a body massindex 〈 26 kg/m2 compared to those with an index ≥ 26kg/m2 （4.0 ± 1.1 kPa vs 4.6 ± 1.2 kPa; P 〈0.05）. Therewere no differences in hospital stay or postoperativebilirubin, albumin,alanine and aspartate transaminases,or creatinine levels （at discharge） between donors withlivers stiffness ≤ 4 kPa and those with stiffness 〉 4 kPa.CONCLUSION： Healthy donors with normal liverhistology have a median LS of 4 kPa. Stiffness valuesare elevated relative to increase in body mass index.
