摘要
AIM: To compare the ability of model for end-stage liver disease(MELD)-Na and Maddrey discrimination function index(DFI) to predict mortality at 30 and 90 d in patients with alcoholic hepatitis(AH).METHODS: We prospectively assessed 52 patients with AH. Demographic, clinical and laboratory parameters were obtained. MELD-Na and Maddrey DFI were calculated on admission. Short-term mortality was assessed at 30 and 90 d. Receiver operating characteristic curve analysis was performed. RESULTS: Thirty-day and 90-d mortality was 44% and 58%, respectively. In the univariate analysis, sodium levels was associated with mortality at 30 and 90 d(P = 0.001 and P = 0.03). Child stage, encephalopathy, ascites, or types of treatment were not associated with mortality. MELD-Na was the only predictive factor for mortality at 90 d. For 30-d mortality area under the curve(AUC) was 0.763(95%CI: 0.63-0.89) for Maddrey DFI and 0.784 for MELD-Na(95%CI: 0.65-0.91, P = 0.82). For 90-d mortality AUC was 0.685(95%CI: 0.54-0.83) for Maddrey DFI and 0.8710 for MELD-Na(95%CI: 0.76-0.97, P = 0.041). CONCLUSION: AH is associated with high shortterm mortality. Our results show that MELD-Na is a more valuable model than DFI to predict short-term mortality.
AIM To compare the ability of model for end-stageliver disease （MELD）-Na and Maddrey discriminationfunction index （DFI） to predict mortality at 30 and 90 din patients with alcoholic hepatitis （AH）.METHODS： We prospectively assessed 52 patientswith AH. Demographic, clinical and laboratory parameterswere obtained. MELD-Na and Maddrey DFI werecalculated on admission. Short-term mortality wasassessed at 30 and 90 d. Receiver operating characteristiccurve analysis was performed.RESULTS： Thirty-day and 90-d mortality was 44% and58%, respectively. In the univariate analysis, sodiumlevels was associated with mortality at 30 and 90 d （P= 0.001 and P = 0.03）. Child stage, encephalopathy,ascites, or types of treatment were not associatedwith mortality. MELD-Na was the only predictivefactor for mortality at 90 d. For 30-d mortality area under the curve （AUC） was 0.763 （95%CI： 0.63-0.89）for Maddrey DFI and 0.784 for MELD-Na （95%CI：0.65-0.91, P = 0.82）. For 90-d mortality AUC was 0.685（95%CI： 0.54-0.83） for Maddrey DFI and 0.8710 forMELD-Na （95%CI： 0.76-0.97, P = 0.041）.CONCLUSION： AH is associated with high shorttermmortality. Our results show that MELD-Na is amore valuable model than DFI to predict short-termmortality.
