微量元素联合兰菌净预防老年人呼吸道感染的临床研究

Clinical studies of trace elements combined with Lantigen in the prevention of respiratory tract infections in elderly patients

目的：研究多种微量元素联合兰菌净预防老年人呼吸道感染效果，以期为老年人预防呼吸道感染提供参考依据。方法选取于2003年1月－2010年3月进行健康体检人员98名，年龄52～71岁、平均（61＆#177;4．2）岁，随机分为研究组51名和对照组47名，研究组给予兰菌净舌下滴入联合微量元素口服，对照组单纯给予多种微量元素口服用药，比较两组老年人用药前后免疫球蛋白（IgA、IgG、IgM ）含量变化及用药后1年内发生呼吸道感染次数，数据采用SPSS17．0进行统计分析。结果用药前两组老年人免疫球蛋白水平差异无统计学意义，用药后两个月研究组IgA、IgG含量均高于对照组，差异有统计学意义（P＜0．05），两组IgM 指标差异无统计学意义；对两组老年人进行随访，1年内51名研究组发生1、2次及≥3次呼吸道感染发生率分别为21．57％、9．80％及1．96％，明显低于对照组的40．43％、12．77％及10．64％，差异有统计学意义（ P＜0．05）。结论多种微量元素联合兰菌净能有效预防与减少老年人呼吸道感染次数，免疫球蛋白均有所增加。

OBJECTIVE To study the trace elements combined with Lantigen in the prevention of respiratory tract infections in elderly patients so as to provide a reference for clinical diagnosis and treatment .METHODS From Jan .2003 to Mar .2010 ,98 elderly patients aged 52 to 71 received health examination .The average age of them was （61±4 .2） years .They were divided into study group with 51 cases and control group with 47 cases .The study group was given sublingual drops of Lantigen combined with oral trace elements ,while the control group was adopted multi oral use trace elements only .The levels of immune globulin （IgA ,IgG and IgM ） were com‐pared between the two groups after the treatments and the respiratory tract infection appearing time were counted during a year .All data were statistically analyzed by SPSS 17 .0 software .RESULTS No significant differences were found between the two groups before the treatments ,but after adopting different treatments for two months , IgA and IgG levels in the study group were higher than those of the control group and the differences were signifi‐cant （P〈0 .05） .IgM level didn＆#39;t show any significant difference in the two groups .The follow‐up visit results showed that within the year ,respiratory tract infection occurred for once ,twice and three times accounted for 21 .57% ,9 .80% and 1 .96% respectively in the study group ,which were statistically lower than those in the con‐trol group of 40 .43% ,12 .77% and 10 .64% （P〈0 .05） .CONCLUSION Multiple trace elements combined with Lantigen can effectively prevent and reduce the frequency of respiratory tract infections in elderly people and can increase the number of immune globulin .