摘要
目的探讨晚期肺癌患者化疗期间并发医院感染的危险因素,为预防肺癌化疗患者医院感染提供科学依据。方法回顾性分析2009年5月-2013年5月医院收治的晚期肺癌化疗患者共527例,调查分析患者感染因素,数据采用SPSS 19.0软件进行统计分析。结果调查527例患者中发生医院感染106例,感染率为20.11%;共分离出病原菌128株,以革兰阴性菌为主,共71株占55.47%;非条件多因素logistic回归分析显示,侵入性操作、住院时间、预防性使用抗菌药物及年龄与患者发生医院感染密切相关,是晚期肺癌患者化疗期间发生医院感染的独立危险因素(P<0.05)。结论侵入性操作、住院时间长、预防性使用抗菌药物及患者高龄是肺癌晚期患者化疗期间并发医院感染的独立危险因素,对于具有感染高风险的患者应在临床中做好相应的重点监护工作,重视对患者的免疫支持治疗。
OBJECTIVE To explore the risk factors for nosocomial infections in the advanced lung cancer patients during the chemotherapy so as to provide scientific basis for prevention of the nosocomial infections in the lung cancer patients undergoing the chemotherapy .METHODS A total of 527 patients with advanced lung cancer who underwent the chemotherapy from May 2009 to May 2013 were retrospectively analyzed ,then the risk factors for the infections were investigated ,and the statistical analysis of data was performed with the use of SPSS 19 .0 soft‐ware .RESULTS The nosocomial infections occurred in 106 of 527 patients ,with the infection rate of 20 .11% . Totally 128 strains of pathogens have been isolated ,of which 71 (55 .47% ) were the gram‐negative bacteria .The non‐conditional multivariate logistic regression analysis indicated that the incidence of the nosocomial infections was closely associated with the invasive operation ,length of hospital stay ,antibiotics prophylaxis ,and age ,which were the independent risk factors for the nosocomial infections in the patients with advanced lung cancer during the chemotherapy (P〈0 .05) .CONCLUSION The invasive operation ,long length of hospital stay ,antibiotic prophy‐laxis ,and advanced age are the independent risk factors for the complicated nosocomial infections in the patients with advanced lung cancer during the chemotherapy .It is necessary for the hospital to focus on the monitoring of the patients at high risk of infections and pay attention to the immune supportive treatment .
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2015年第15期3477-3479,共3页
Chinese Journal of Nosocomiology
基金
浙江省医药卫生基金资助项目(2011KYA114)
关键词
晚期肺癌
化疗
医院感染
危险因素
Advanced lung cancer
Chemotherapy
Nosocomial infection
Risk factor