海口市不同人群输血传播病毒感染调查

Detection of transfusion transmitted virus in different populations in Haikou city

目的了解海口市不同人群中输血传播病毒(Transfusion transmitted virus,TTV)的感染状况,为进一步探究TTV的传播途径提供基本依据。方法于2013年1-12月采用半巢试PCR技术对530例患者及116名健康体检者血清中的TTV-DNA进行检测,数据采用SPSS18.0进行统计分析。结果 646例不同人群的血清样本,共检测出TTV-DNA阳性160例,阳性率24.77%,其中静脉吸毒患者阳性率最高,阳性率为41.38%,其次为性病高危人群,阳性率为37.35%,健康体检者的阳性率最低,阳性率为10.34%;TTV与HBV合并感染最常见,其次是HCV,单独TTV感染的阳性率为16.67%。结论海口市人群中存在较为广泛的TTV感染,其中静脉吸毒者和性病患者是TTV感染的高危人群。

OBJECTIVE To investigate the prevalence of transfusion transmitted virus （TTV） in different popula‐tions in Haikou city , in order to provide basis for further exploration of the transmission route of TTV . METHODS The TTV DNA was detected in 646 serum samples from different populations including 530 patients and 116 healthy people by nest PCR in Jan .2013 to Dec .2013 .The software SPSS18 .0 was used for statistical a‐nalysis of data .RESULTS A total of 646 serum samples from different populations were detected by nest PCR , and the positive rate of TTV DNA was 24 .77% （160/646） .The highest positive rate was seen in intravenous drug users （IVDUs） ,41 .38% ,followed by high risk population of sexually transmitted disease （STD） ,37 .35% . The positive rate of normal population was the lowest ,10 .34% .Among multi‐infectious cases ,the infection rate of TTV complicated by HBV was the highest ,followed by TTV complicated by HCV ,and the positive rate of TTV infection alone was 16 .67% .CONCLUSION The investigation showed that the infection of TTV was rather widely spread in Haikou city .IVDUS and STD high risk populations were the high risk populations for TTV in‐fection .