门体静脉分流术患者应用甘露聚糖肽对术后感染的预防研究

Study of mannatide in the prevention of infections in patients after received operation of portosystemic shunt infection complications

目的探讨门体静脉分流术患者应用甘露聚糖肽对预防手术感染并发症的作用,为临床治疗提供参考依据。方法从医院2013年1月-2014年1月收治的行门体静脉分流术患者中随机选择100例进行研究,将其分为观察组和对照组,各50例,分别给予生理盐水和同剂量甘露聚糖肽静脉滴注,观察两组患者手术感染并发症情况,数据采用SPSS 15.0软件进行统计分析。结果术后4、7d,观察组的治疗总有效率分别为86.0%和90.0%,对照组分别为82.0%和84.0%,观察组高于对照组,但经比较差异无统计学意义;两组患者术后并发症发生率分别为6.0%和10.0%,经比较差异无统计学意义;但观察组的术后住院时间为(16.25±3.15)d,显著短于对照组的(19.03±3.95)d,差异有统计学意义(P<0.05)。结论门体静脉分流术患者应用甘露聚糖肽进行静脉滴注,可以有效预防手术感染并发症,效果显著。

OBJECTIVE To explore the function of mannatide in the prevention of infections and complications oc‐curred in patients after receiving portosystemic shunt so as to provide references for clinical treatments . METHODS Totally 100 cases of patients accepted portosystemic shunt in our hospital from Jan .2013to Jan .2014 were selected and divided into two groups with 50 patients in each group .All of the patients were given normal sa‐line and the same dose of mannatide intravenous drip .The complications and infection condition of the two groups were observed and compared .All data were analyzed by SPSS 15 .0 software .RESULTS The effective rates on the day 4 and day 7 of the observation group were respectively 86% and 90% ,which were higher than those of the control group with the rate of respectively 82 .0% and 84 .0% .But the differences between the two groups were not significant（χ2 =3 .12 ,P〉0 .05） .The postoperative complication rates of the two groups were 6% and 10%respectively ,and the differences between the two groups were not significantly （χ2 =5 .32 ,P〉0 .05） .The hospi‐talization time after operation of the observation group was （16 .25 ± 3 .15d） ,which were significantly shorter than that of the control group with （19 .03 ± 3 .95d） （t=12 .11 , P〈0 .05） .CONCLUSION Intravenous drip of man‐natide can effectively prevent infections and complications in patients who received operation of portosystemic shunt .