Wnt5a、Sfrp5水平与寻常型银屑病及肥胖的相关性分析

The Relationship between Plasma Wnt5a and Sfrp5 Levels and Obesity in Psoriasis Vulgaris

目的:探讨Wnt5a、Sfrp5水平与寻常型银屑病及肥胖的关系。方法:收集正常人和寻常型银屑病血浆,分为非肥胖正常人组、肥胖正常人组、非肥胖银屑病组和肥胖银屑病组,每组各20例。采用ELISA检测血浆Wnt5a及Sfrp5水平,比较组间血浆Wnt5a及Sfrp5水平并作相关分析。结果:与非肥胖正常人组血浆Wnt5a水平(0.082±0.054)ng/m L比较,非肥胖银屑病患者[(0.105±0.049)ng/m L]和肥胖银屑病患者[(0.320±0.155)ng/m L]血浆Wnt5a水平明显升高(P值均<0.01),肥胖正常人群组[(0.105±0.049)ng/m L]无明显改变。非肥胖正常人组血浆Sfrp5水平为(75.11±19.72)ng/m L,肥胖正常人组[(55.85±13.65)ng/m L]、非肥胖银屑病组[(58.09±16.78)ng/m L]及肥胖银屑病组[(52.21±15.72)ng/m L]血浆Sfrp5水平较其降低(P值均<0.05)。结论:Wnt5a及Sfrp5可能与寻常型银屑病及肥胖发生发展相关,是联系银屑病和代谢综合征之间的重要介质。

Objective ：To explore the relationship between plasma WntSa and Sfrp5 levels and obese of patients with psoriasis vulgaris. Methods：20 non-obese controls, 20 obese controls, 20 non-obese psoriasis patients and 20 obese psoriasis patients were enrolled in this study. Plasma WntSa and Sfrp5 concentrations were measured through enzyme-linked immunosorbent assay （ELISA） and compared. Results ： Wnt5a was significantly higher in non-obese patients with psori- asis （0. 105 ±0. 049 ng/mL） and obese psoriasis patients （0. 320 ± 0. 155 ng/mL） compared with non-obese healthy controls （0. 082 ±0. 054 ng/mL） （both P 〈0. Ol ）. Sfrp5 was significant- ly lower in obese healthy men （55.85 ± 13.65 ng/mL, P =0. 001 ） and non-obese patients with psoriasis vulgaris （58.09 ±16. 78 ng/mL, P = O. O1 ） compared with non-obese healthy controls （75.11 ± 19.72 ng/mL）. Conclusion：Wnt5a and Sfrp5 may play a role in psoriasis vulgaris and obesity, and they may be an important media of psoriasis and metabolic syndrome.