丹天颈舒胶囊对椎动脉型颈椎病家兔血液流变学的影响

Effect of Dantian Jingshu Capsule on Hemorheology of CSA Model Rabbits

目的:研究丹天颈舒胶囊对家兔椎动脉型颈椎病(CSA)模型血液流变学的影响。方法:日本大耳兔随机分为正常组,模型组,丹天颈舒胶囊0.36,0.72,1.44 g·kg-1剂量组,颈复康颗粒阳性药组1.0 g·kg-1,西比灵组0.001 g·kg-1;采用775组织硬化剂注射家兔左侧颈椎横突切迹周围肌肉制作椎动脉颈椎病模型,造模后普通饮水饮食,均于第8周开始ig,每日1次。正常组及模型组不作任何治疗处理。连续ig2周后测定家兔全血表观黏度、血浆黏度、全血还原黏度,红细胞压积(HCT),红细胞刚性指数(ERI),红细胞聚集指数(FAI)和红细胞变形指数EDI的变化。结果:与正常组比较,模型组的全血黏度,血浆黏度,HCT,EAI,全血还原黏度的变化均呈显著性提高(P<0.01)。与模型组比较,丹天颈舒胶囊高、中、低剂量组能明显降低CSA家兔的血液黏度(P<0.01),明显降低CSA家兔血液中红细胞的聚集(P<0.05),增强红细胞变形能力而降低血液黏度(P<0.01)。结论:丹天颈舒胶囊能改善CSA家兔的血液流变学,其机制可能是使红细胞聚集减少,红细胞变形能力增强降低血液黏度从而改善头部缺血症状。

Objective： To investigate the effect of Dantian Jingshu capsule onhemorheology of vertebral artery type cervical spondylosis（ CSA） model rabbits. Method： Seventy rabbits were randomly divided into 7groups： normal group,model group,Dantian Jingshu capsule group（ 0. 36,0. 72,1. 44 g ·kg^-1）,positive control group（ Jing Fukang granules 1. 0 g·kg^-1and flunarizine 0. 001 g·kg^-1）. Rabbits were injected with 775injection（ tissue sclerosing agent） in the left side of cervical vertebrae to make animal model of CSA. To observe the effects of Dantian Jingshu capsule on hemorheology [whole blood viscosity,plasma viscosity,whole blood viscosity reduction,hematocrit（ HCT）,erythroeyte aggregation index（ EAI）,red cell rigidity index（ ERI）,red cell deformation index（ EDI） and fibrinogen]of the rabbits by intragastric administration after two weeks. Result：Compared with normal group,the hemorheology index of model group（ blood viscosity,plasma viscosity,HCT,whole blood viscosity reduction,EAI） were obviously decrease. So there was significant differences between normal group and model group（ P〈0. 01）. Compared with model group,blood viscosity and aggregation of red-cells were obviously decrease and erythrocyte deformability was increased in Dantian Jingshu capsule group（ P〈0. 01）.Conclusion： Dantian Jingshu capsule could reduce the CSA model rabbits erythrocyte aggregation and reinforce the ability of erythocyte deformability so that improve its blood viscosity. Dantian Jingshu capsule can improve the CSA model rabbits＇ symptom of cerebral ischaemia.