中医学“内生浊邪”本质探讨

Exploration of the Essence of "Endogenous Turbidity" in Chinese Medicine

中医学"内生浊邪"本质上不同于"膏、脂、痰、饮、湿、毒、瘀"。随着现代科学技术和生物学发展,"内生浊邪"本质的研究应与时俱进,对其物质基础当予以界定,应赋予微观层面的新内涵。浊的本质是因脏腑功能异常,糖、脂、蛋白质等精微物质化生不成熟,而成为半成品复合物或中间代谢产物,没有活性,不能参与正常的物质合成和分解代谢,既不能直接被转化为能量代谢,又不能合成为有活性的蛋白质执行功能,如果不能被机体的自噬溶酶体或泛素蛋白酶体降解成葡萄糖、脂肪酸、氨基酸等基础营养物质重新被利用,积聚体内,而成了真正意义上的"内生浊邪"。因此"内生浊邪"不同于机体的最终代谢产物,如尿素、二氧化碳等,它具有转化正气的一面。如何提高脏腑功能,增强细胞的自噬溶酶体或泛素蛋白酶体对其的降解,对脏腑功能的正常运行、防止相关疾病的产生和进展具有重要的意义。

The essence of endogenous turbidity in Chinese medicine （CM） is different from cream, fat, phlegm, retention, damp, toxicity, and stasis. Along with the development of modern scientific technologies and biology, researches on the essence of endogenous turbidity should keep pace with the time. Its material bases should be defined and new connotation endowed at the microscopic level. The essence of turbidity lies in abnormal functions of zang-fu organs. Sugar, fat, protein, and other nutrient substances cannot be properly decomposed, but into semi-finished products or intermediate metabolites. They are inactive and cannot participate in normal material syntheses and decomposition. They cannot be transformed to energy metabolism, but also cannot be synthesized as executive functioning of active proteins. If they cannot be degraded by autophagy-lysosome or ubiquitin-prosome into glucose, fatty acids, amino acids, and other basic nutrients to be used again, they will accumulate inside the human body and become endogenous turbidity. Therefore, endogenous turbidity is different from final metabolites such as urea, carbon dioxide, etc., which can transform vital qi. How to improve the function of zang-fu organs, enhance its degradation by autophagy-lysosome or ubiquitin-prosome is of great significance in normal operating of zang-fu organs and preventing the emergence and progress of related diseases.