生大黄外用干预老年急性痛风性关节炎的临床观察

Clinical Observation on the External Treatment of Acute Gouty Arthritis in Elderly Patients with Sheng Dahuang

目的观察生大黄粉醋调外敷治疗急性痛风性关节炎的疗效。方法 64例患者按随机数字表法随机分为治疗组与对照组各32例。对照组给予口服非甾体类消炎药治疗,治疗组在对照组基础上给予生大黄粉醋调外敷患处治疗。观察两组分析关节疼痛、关节肿胀、临床疗效及安全性。结果治疗组中医临证疗效总有效率87.50%,明显高于对照组的56.26%(P<0.05)。两组治疗后关节发热积分、关节疼痛积分均改善(P<0.05),且治疗组改善优于对照组(P<0.05)。治疗组治疗后与治疗前比较关节肿胀积分改善(P<0.05),而对照组治疗前后关节肿胀积分差别不大(P>0.05),治疗组关节肿胀积分改善优于对照组(P<0.05)。两组治疗后与治疗前比较关节活动度积分均改善(P<0.05),而两组治疗后关节活动度积分差别不大(P>0.05)。两组不良反应发生差别不大(P>0.05)。未见过敏、皮疹及其他严重不良反应。结论生大黄粉醋调外敷患处治疗急性痛风性关节炎具有"简、便、廉、效"的特色。

Objective： To observe the curative effect of Sheng dahuang powder with vinegar on the external treatment of acute gouty arthritis. Methods： 64 patients were randomly divided into treatment group and control group, 32 cases in each group. The control group was given oral non steroidal anti-inflammatory drug treatment, The treatment group based on the control group were given Sheng dahuang powder with vinegar adjustable on topical lesion. The two groups were observed in the analysis of joint pain,joint swelling,clinical efficacy and safe- ty. Results： The total effective rate of TCM in treatment group was 87.50% ,which was significantly higher than that of the control group （56.26%）（P〈 0.05）. After treatment,the two groups were improved in heat and pain score of joint integral（P〈 0.05）,and the treatment group was better than the control group（P〈 0.05）. The treat- ment group before and after treatment compared with joint swelling score improved （P〈 0.05）,while the control group before and after treatment of joint swelling integral difference （P〉 0.05） ,the treatment group joint swelling score better than the control group（P 〈 0.05 ）. The activity of the joint was improved in the two groups before and after treatment （P〈 0.05）,but the difference of the score of the two groups was not significant （P〉 0.05）. There was no difference in adverse reactions between the two groups （P〉 0.05 ）. No allergic reaction, rash and other seri- ous adverse reactions. Conclusion： Sheng dahuang powder with vinegar on the external treatment of acute gouty arthritis has ＂Simple,convenient,cheap,effective＂ characteristics.