汉防己甲素对晚期非小细胞肺癌的放疗增敏作用

Radiosensitization effect of tetrandrine on advanced non-small-cell lung cancer

目的研究汉防己甲素(Tet)对晚期非小细胞肺癌的放射增敏作用及不良反应。方法经病理学或细胞学确诊的82例晚期非小细胞肺癌患者,首程治疗均给以放疗,分为3组:Tet组、紫杉醇组及单纯放疗组。Tet组30例从放疗第1天开始服用Tet,每天3次,每次40mg,直至放疗结束。紫杉醇组29例在放疗期间每周静脉滴注紫杉醇1次,每次60mg。单纯放疗组23例仅行放疗。结果 Tet与紫杉醇有相同的放疗增敏作用,两者总有效率均高于单纯放疗组,差异有统计学意义(P<0.05)。放射性肺炎总发生率Tet组明显低于其余两组(P<0.05)。Tet组一年内无病生存率高于其他两组。结论 Tet有紫杉醇相当的放疗增敏作用,并能减轻放疗不良反应。

Objective To study the radiosensitization effects of tetrandrine on advanced non small cell lung cancer and its toxicity. Methods The patients of 82 cases with advanced non-small cell lung cancer were confirmed by pathology or cytology. The first course of treatment was treated with radiation therapy. Patients were divided into three groups： tetrandrine group, paclitaxel group and radiotherapy group. Tetrandrine group（30 cases） took radiotherapy with 40 mg tetrandrine（3 times a day） from the first day to the ending. Paclitaxel group （29 cases） took radiotherapy with intravenous infusion of 60 mg paclitaxcl（once a week）. Radio- therapy group （23 cases） only received radiotherapy. Results Tetrandrine and paclitaxel had the same radiosensitizing effect in ra- diotherapy. The total effective rate of tetrandrine and paclitaxel group was higher than radiotherapy group （P〈0.05）. The inci- dence of radiation pneumonitis in tetrandrine group was significantly lower than the other two groups （P〈0.05）. The one year free disease survival rate was promoted in tetrandrine group than other groups. Conclusion Tetrandrine was known as the same radia- tion sensitizing effect of paclitaxel fairly,which can reduce the toxicity of radiotherapy.