冠心病合并微量清蛋白尿与心血管事件的相关研究

Correlation between microalbuminuria and cardiovascular events in patients with coronary heart disease

目的探讨冠心病合并微量清蛋白尿(MAU)与心血管事件的相关性。方法连续选择该院冠心病患者共120例,根据尿清蛋白肌酐比值(UACR)分为观察组(30mg/g<UACR<300mg/g,n=80)和对照组(UACR≤30mg/g,n=40),随访15个月后比较分析两组患者心血管事件与MAU水平的相关性。结果观察组的MAU水平显著高于对照组,差异有统计学意义(P<0.05)。观察组患者的心血管事件共发生163次,对照组57次,观察组的心血管事件发生率显著高于对照组,差异有统计学意义(t=3.717,P<0.05)。Spearman相关分析可知,MAU与心血管事件呈显著正相关(r=0.721,P<0.01)。影响因素有MAU(P=0.001)、C反应蛋白(P=0.037)。结论 MAU浓度与冠心病患者心血管事件密切相关,可以预测心血管事件的发生。

Objective To investigate the correlation between microalbuminuria and cardiovascular events in patients with coronary heart disease. Methods A total of 120 CHD patients were divided into experiment group （30 mg/g〈 UACR〈300 mg/g, n：80）and control group（UACR≤30 mg/g,n= 40） The relationship between MAU and cardiovascular events rate was compared after 15 months. Results Microalbuminuria level in experiment group was significantly higher than control group（P^0.05）. The incidence of cardiovascular event in experiment group was significantly higher（t= 3. 717, P〈0.05）o MAU and cardiovascular e- vents were positively related by Spearmanls analysis（r= 0. 721, P〈0.01）. The effective factors were MAU and CRP（MAU：P 0. 001; CRP;P=0. 037）. Conclusion MAU concentration had a great impact on the incidence of cardiovascular event. The incidence of cardiovascular might be predicted by the MAU.