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蛋白因子Vasohibin-1的研究进展

Research progress on Vasohibin-1
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摘要 Vssohibin-1(VASH1)作为新近发现的的蛋白因子,其具有负反馈调节血管生成作用,是由血管内皮生长因子(vascular endothelial growth factor,VEGF)、成纤维生长因子2(fibroblast growth factor-2,FGF2)等诱导产生,在多种肿瘤血管生成中扮演着重要的角色,不但可以抑制肿瘤的血管生成,而且对于肿瘤淋巴管生成和淋巴结转移也有强大的抑制作用,提示其有望成为相关肿瘤诊断和治疗的分子标志物以及分子靶向治疗的有效蛋白因子。 Vasohibin-1（VASH1）is induced in response to angiogenesis stimuli such as vascular endothelial factor （VEGF）and fibroblast growth-2（FGF-2）,has recently been isolated as a novel negative feedback inhibitor of an-giogenesis. It plays important roles in the development of various tumors ,such as inhibit angiogenesis,tumor lym-phangiogenesis and lymphatic metastasis,it would polentially be a biomarker and a candidate for molecular targeted therapy for patients wirh cancer in the future.
作者 孙鑫 谷楠 李娜 王丽丽 吕珊珊 魏秀峰
机构地区 吉林大学口腔医院黏膜病科
出处 《现代肿瘤医学》 CAS 2015年第17期2529-2532,共4页 Journal of Modern Oncology
关键词 Vssohibin-1 血管生成 内皮细胞 肿瘤 angiogenesis endothelial cell tumor
分类号 R730.5 [医药卫生—肿瘤]
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参考文献35

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二级参考文献44

  • 1Carmeliet P. Angiogenesis in health and disease [ J ]. Nat Med, 2003, 9, 653 - 660.
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  • 3Shibuya T, Watanabe K, Yamashita H, et al. Isolation and characterization of VA - SH2 as a homologue of VEGF -inducible endotheliumderived angiogenesis inhibitor VASH [ J ]. Arterioscler Thromb Vasc Biol , 2006, 26 : 1051 - 1057.
  • 4Kern J, Bauer M, Rychli K, et al. Ahernative splicing of VASH1 generates an inhi - bitor of endothelial cell prolif- eration, migration and capillary tube formation [ J ]. Arte- rios - cler Thromb Vasc Biol ,2008, 28:478 - 84.
  • 5Kimura H, Miyashita H, Suzuki Y, et al. Distinctive lo- calization and opposed roles of vasohibin - 1 and vasohibin -2 in the regu -lation of angiogenesis [ J ]. Blood, 2009, 113:4810-4818.
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  • 10Sonoda H, Ohta H, Watanabe K, et al. Multiple pro- cessing forms and their biolo - gical activities of a novel angiogenesis inhibitor vasohibin [ J ]. Biochem Biophys Res Commun, 2006, 342 : 640 - 646.

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现代肿瘤医学
2015年 第17期

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