摘要
nesfatin-1是最近研究发现的一种新的厌食分子。其前体蛋白核连蛋白2(NUCB2)水解形成3个片段:nesfatin-1、nesfatin-2和nesfatin-3。nesfatin-1的中间片段(M30)具有强烈的抑制摄食的作用,nesfatin-2和nesfatin-3不抑制摄食且其生物学功能目前尚不清楚。此外,nesfatin-1还参与行为、情绪、生殖、睡眠、癫痫和糖尿病等的调控。作者综述了nesfatin-1的发现、命名、结构、分布、主要的生物学功能及其抑制摄食的机制。
The recently discovered nesfatin-1 is a new anorexigenic molecule. The precursor pro- tein nucleobindin-2 （NUCB2） is proteolytically cleaved into three fragments,nesfatin-1 ,nesfatin-2 and nesfatin-3. The middle segment of nesfatin-1 （M30） is responsible for inhibiting food intake, while the physiological role of nesfatin-2 and nesfatin-3 are not currently known yet. nesfatin-1 plays roles in behaviour, mood, reproduction, sleeping, epilepsy and diabetic hyperphagia. We re- viewed the discovery, designation, biochemical structure, distribution, its main biological function and the possible mechanism of inhibiting food intake effect of nesfatin-1.
出处
《中国畜牧兽医》
CAS
北大核心
2015年第8期2058-2065,共8页
China Animal Husbandry & Veterinary Medicine
基金
国家大宗淡水鱼产业技术体系专项基金
