表皮生长因子受体运输与肿瘤治疗的研究进展

Correlation study of endothelial growth factor receptor transportation with tumor treatment

表皮生长因子受体(EGFR)信号传导异常参与了肿瘤的发生发展,已经作为抗肿瘤治疗的靶点。本文在EGFR信号传导失调相关机制的基础上,对EGFR信号传导过程中产生的运输异常及其癌基因的相互作用、EGFR靶向药物在肿瘤治疗中的应用作一综述,以期为以EGFR为靶点的肿瘤治疗方法以及其参与肿瘤耐药相关的最新研究提供参考。

Abnormal endothelial growth factor receptor transportion was involved in the development of tumor so more and more researches focus it as a target of anti-tumor therapy. Based on the known mechanism in EGFR mis-localization this review summarized the latest research progress in the abnormality in signal of EGFR transportation and its role in tumori- genesis, anti-tumor drug and therapy that target to EGFR. It is aim to provide reference for the development of anti-tumor treatments which target EGFR and for the mechanism in resistance of anti-tumor.