中枢神经系统感染患者脑脊液检查的结果分析

Analysis of the results of cerebrospinal fluid examination in patients with central nervous system infections

目的分析脑脊液不同成分在不同中枢神经系统感染性疾病中的含量,探讨在中枢神经系统感染性疾病诊断中脑脊液检查的应用,为临床提供参考依据。方法选取2012年1月-2014年1月中枢神经系统感染患者90例,分为病毒性脑膜炎组、结核性脑膜炎组及化脓性脑膜炎组各30例,同期选取中枢神经系统非感染性疾病患者30例为对照组,比较4组患者临床资料;检测中枢神经系统感染患者9脑脊液中的乳酸脱氢酶、肌酸激酶和乳酸指标,并进行比较;数据采用SPSS 19.0软件进行统计分析。结果患者检测乳酸脱氢酶病毒性脑膜炎组为(17.23±6.87)U/L,结核性脑膜炎组为(84.33±17.34)U/L,化脓性脑膜炎组为(71.43±16.78)U/L,对照组为(16.98±6.59)U/L,组间比较,差异有统计学意义(P<0.05)。结论在不同中枢神经系统感染性疾病中脑脊液各项指标多数差异有统计学意义,需要综合分析不能单靠一种指标进行确诊。

OBJECTIVE To analyze content of different components of cerebrospinal fluid in different types of cen‐tral nervous system infections so as to provide references for clinical treatments .METHODS From Jan .2012 to Jan .2014 ,totally 90 cases of patients with central nervous system infections were selected and divided into viral meningitis group ,tuberculosis meningitis group and purulent meningitis group with 30 cases each .In the same pe‐riod ,30 patients with non‐infectious diseases were chosen as control group .The clinical data of the four groups were compared ,Indicators such as lactate dehydrogenate （LDH） ,creative kinas （CK） ,and lactic acid （LA） con‐tent were detected and compared in the cerebrospinal fluid of the infected patients .RESULTS LDH level was （17 .23 ＆#177; 6 .87） U/L in the viral meningitis group ,（84 .33 ＆#177; 17 .34） U/L in the tuberculosis meningitis group ,and （71 .43 ＆#177; 16 .78） U/L in the purulent meningitis group .In the control group ,the level was （16 .98 ＆#177; 6 .59） U/L . The differences were significant （P〈0 .05） .CONCLUSION In different types of infections in the central nervous system ,differences of most indicators in cerebrospinal fluid were significant .Definite diagnosis can be made by comprehensive analysis instead of analyzing by single indicator .