人乳头状瘤病毒感染与宫颈疾病的相关性研究

Correlation between human papillomavirus infection and cervical diseases

目的探讨人乳头状瘤病毒(HPV)感染与宫颈疾病之间的相关性,为宫颈疾病的筛查提供依据。方法选取2012年1月-2013年12月于医院接受治疗的宫颈疾病患者2 016例,进行薄层液基细胞学检测(Thinprep cytologic test,TCT)、HPV及病理学检查,研究三者之间的关系,数据采用SPSS 17.0进行统计分析。结果 HPV感染阳性率为9.62%;高度鳞状上皮内病变(HSIL)、低度鳞状上皮内病变(LSIL)、非典型鳞状上皮细胞(ASCUS)HPV感染率分别为69.05%、61.54%、22.40%,非典型鳞状上皮细胞明显低于高度鳞状上皮内病变及低度鳞状上皮内病变;HPV检测阳性与病理学检查的阳性符合率为65.93%,TCT与病理学检查的阳性符合率为80.00%;随着宫颈病变级别的增加,TCT和HPV阳性率也不断升高。结论宫颈癌和宫颈癌前病变主要致病因素之一为HPV感染,HPV和TCT联合检测有助于早期发现及早期诊断宫颈病变。

OBJECTIVE To explore the correlation between the human papillomavirus （HPV） infection and the cer‐vical diseases so as to provide guidance for screening of the cervical diseases .METHODS A total of 2 016 patients with cervical diseases who were treated in the hospital from Jan 2012 to Dec 2013 were enrolled in the study .The thinprep cytologic test （TCT） ,HPC ,and pathological examination were carried out ,the relationship among the three was observed ,and the statistical analysis of data was performed with the use of SPSS 17 .0 software . RESULTS The positive rate of HPV infection was 9 .62% .The incidence of HPV infection was 22 .40% in the pa‐tients with atypical squamous cells ,significantly lower than 69 .05% in the patients with high‐grade squamous in‐traepithelial lesion （HSIL ） and 61 .54% in the patients with low‐grade squamous intraepithelial lesion （LSIL ） . The positive coincidence rate between the positive detection of HPV and the pathological examination was 65 .93% ;the positive coincidence rate between the TCT and the pathological examination was 80 .00% .With the increase of grade of the cervical diseases , the positive rates of TCT and HPV were constantly increased . CONCLUSION The HPV infection is one of the leading cause of cervical cancer and cervical precancerous lesions . The joint detection of HPV and TCT may contribute to the early diagnosis of cervical lesions .