儿童急性非典型呼吸道感染的病原学研究

Etiological study of pediatric cases with acute atypical respiratory infections

目的了解佛山地区急性非典型呼吸道感染患儿的病原体流行病学特点和发病率,为临床诊断和治疗提供参考依据。方法收集2012年1月-2013年12月医院收治的8 698例急性呼吸道感染患儿进行检测分析,数据采用SPSS 17.0软件进行统计分析。结果在8 698例急性呼吸道感染患儿中,9种呼吸道病原体IgM抗体阳性3 289例,阳性率为37.8%;在3 289例阳性病中有641例存在混合感染,以肺炎支原体合并流感病毒B、肺炎支原体合并腺病毒、肺炎支原体合并呼吸合胞病毒多见;肺炎支原体合并其他病原体感染的IgM抗体阳性率高达93.3%。结论肺炎支原体为佛山地区儿童急性非典型呼吸道感染的主要病原体,9种呼吸道病原体IgM抗体联合检测,为儿童急性非典型呼吸道感染的诊断提供重要依据。

OBJECTIVE To investigate the epidemiological characteristics and the incidence rate of pediatric atypical respiratory infections so as to provide the basis for clinical diagnosis and treatment .METHODS The serum samples were collected from 8698 cases of children with acute respiratory infections admitted in the hospital from Jan .2012 to Dec .2013 .Indirect immunofluorescence was applied to detect the IgM antibody .All data were statistically ana‐lyzed by SPSS 17 .0 software .RESULTS Among the 8698 pediatric cases with acute respiratory infections ,the positive IgM antibodies of 9 kinds of respiratory pathogens were found in 3298 cases ,with the positive rate of 37 .8% .Among them ,641 cases were found to have mixed infections ,mainly caused by Mycoplasma pneumonia （MP） combined with influenza B virus ,with adenovirus ,or with respiratory syncytial virus .The positive rate of IgM antibodies in infections caused by M . pneumoniae combined with other pathogens was over 93 .3% . CONCLUSION MP is the leading cause of pediatric acute atypical respiratory infections in Foshan .The combined detection of IgM antibodies of 9 kinds of respiratory pathogens in the pediatric cases with acute atypical respiratory infections in Foshan provides an important basis for the diagnosis .