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抗苗勒管激素在女性的产生及一生中的变化 被引量：11

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摘要 抗苗勒管激素（anti-Müllerian hormone,AMH）是转化生长因子-β（TGF-β）超家族成员之一,类似于抑制素和激活素。AMH最初被称为苗勒管抑制物质（müllerian-inhibiting substance,MIS）。自20世纪40年代其在早期胚胎发育的男性性分化过程中的作用被人们所认识,早在妊娠8周时睾丸即可以产生AMH,诱导苗勒管的退化,使中肾管（wolffian）在雄激素的作用下发育为男性生殖道。在缺乏AMH的情况下,胚胎将向雌性发育,苗勒管分化成阴道上1/3段、
作者 李敬 韩雪 石玉华
机构地区 山东大学附属生殖医院
出处 《实用妇产科杂志》 CAS CSCD 北大核心 2015年第8期561-562,共2页 Journal of Practical Obstetrics and Gynecology
基金 国家重点基础研究发展计划(编号:973计划 2011CB944502) 国家科技支撑计划(编号:2012BAI32B04) 国家自然基金面上项目(编号:81471428)
关键词 抗苗勒管激素 苗勒管 男性生殖道 抑制物质 抑制素 中肾管 早期胚胎发育 超家族 性发育 inhibiting
分类号 R339.22 [医药卫生—人体生理学]
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参考文献15

  • 1Weenen C, Laven JS, Von Bergh AR, et al. Anti-Mttllerian hormone expression pattern in the human ovary:potential implications for ini- tial and cyclic follicle recruitment [ J]. Mol Hum Reprod, 2004,10 (2) :77 -83.
  • 2Durlinger AL, Gruijters MJ, Kramer P, et al. Anti-Mtillerian hormone attenuates the effects of FSH on follicle development in the mouse o- vary [ J ]. Endocrinology, 2001,142 ( 11 ) :4891 - 4899.
  • 3Hagen CP, Aksglaede L, Sorensen K, et al. Serum levels of anti- Mtlllerian hormone as a marker of ovarian function in 926 healthy fe- males from birth to adulthood and in 172 Turner syndrome patients [ J ]. J Clin Endocrinol Metab,2010,95 ( 11 ) :5003 - 5010.
  • 4Lashen H, Dunger DB, Ness A, et al. Peripubertal changes in circulat- ing antimullerian hormone levels in girls [ J]. Fertil Steril,2013,99 (7) :2071 -2075.
  • 5Hagen CP,Aksglaede L,Sorensen K,et al. Individual serum levels of anti-Mtlllerian hormone in healthy girls persist through childhood and adolescence : a longitudinal cohort study [ J ]. Hum Reprod, 2012,27 (3) :861 -866.
  • 6Lie Fong S, Visser JA, Welt CK, et al. Serum anti-mtillerian hormone levels in healthy females:a nomogram ranging from infancy to adult- hood [ J]. J Clin Endocrinol Metab ,2012,97 (12) :4650 - 4655.
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同被引文献105

  • 1谭汝宏.血清抗缪勒氏管激素检测在评估二胎备孕妇女卵巢功能中的应用[J].中国科技期刊数据库 医药,2016(7):287-287. 被引量：2
  • 2Rey R, Lukas-Croisier C, Lasala C, et al. AMH/MIS: What we know already about the gene, the protein and its regu- lation[J]. Molecular & Cellular Endocrinology, 2003,211 (sl-2) :21-31.
  • 3Milan6s-Virelles MT, Garcia-Garcfa I, Santos-Herrera Y, et al. Adjuvant interferon gamma in patients with pul- monary atypical mycobacteriosis : A randomized,double - blind, placebo-controlled study[J]. Bmc Infectious Diseas- es,2008,8(1) : 1-13.
  • 4Durlinger AL, V isser JA,Themmen AP. Regulation of o- varian function) the role of AntiM llerian hormone[J]. Re- production, 2002, 124(5) : 601609.
  • 5Hirobe S,He WW,Lee MM,et al. Mullerian inhibiting substance messenger ribonucleic acid expression in granu- losa and Sertoli cells coincides with their mitotic activity[J]. Endocrinology, 1992,131 ( 131 ) : 854-862.
  • 6Christien W, Laven JSE, Bergh ARMV,et al. Anti-mtille- rian hormone expression pattern in the human ovary:Po- tential implications for initial and cyclic follicle recruit- ment[J]. Journal of Oral Pathology,2004,10(2) :77-83.
  • 7Baarends WM, Hoogerbrugge JW, Post M, et al. Anti- mtilerian hormone and anti-mtilerian hormone type II re- ceptor[J]. Reprod, 1995,50(5) : 1238-1243.
  • 8Rajpert-DeMeyts E, Jorgensen N, Graem N, et al. Expres- sion of anti-M llerian hormone during normal and patho- logical gonadal development association with differentiation of Sertoli and granulosa cells[J]. J Clin Endocrinol Metab, 1999,84 ( 10 ): 38363844.
  • 9Fang SL, Visser JA, Welt CK, et al. Serum anti-miillerian hormone levels in healthy females:A nomogram ranging From infancy to adulthood[J]. Journal of Clinical En- docrinology & Metabolism, 2012,97 (12) : 4650-4655.
  • 10Hagen CP, Lise A, Kaspar S,et al. Serum levels of anti- qiillerian hormone as a marker of ovarian function in 926 healthy females from birth to adulthood and in 172 turner yndrome patients[]l. Journal of Clinical Endocrinology &Metabolism, 2010,95 ( 11 ) : 5003-5010.

引证文献11

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实用妇产科杂志
2015年 第8期

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