同步放化疗对不能手术局部晚期胃癌的疗效

Efficacy of chemoradiation in the advanced gastric carcinoma patients without operation

目的:观察同步放化疗对不能手术的局部胃癌晚期(Ⅱ-Ⅲc)患者的近期疗效。方法:将55例不能手术的局部晚期胃癌患者随机分为2组,28例进行同步放化疗治疗,先行XELOX方案化疗1周期,于2周期化疗第2天同时进行适形放疗,并按化疗周期进行3、4周期XELOX方案治疗。27例患者进行4周期XELOX方案化疗。结果:无进展生存期(PFS):同步放化疗组为7.11个月,化疗组为5.13个月(P<0.05);一年生存率同步放化疗组60%高于化疗组51%,两者比较,无统计学意义(P>0.05);肿瘤客观缓解率(ORR)同步放化疗组67.8%,化疗组40.7%(P<0.05);患者卡氏评分两组治疗前后均无统计学意义(P>0.05)。结论:同步放化疗可以提高不能手术局部晚期胃癌患者近期疗效。

Objective：To investigate the efficacy of advanced gastric carcinoma patients （Ⅱ -Ⅲc ）received only chemoradiotherapy without operation.Methods：All 55 cases with locally advanced gastric cancer who can not accept-ed operation were randomly divided into two groups,After treated with XELOX scheme 1 cycle of chemotherapy,28 patients accepted 3 -dimensional conformal radiation therapy in the second day of the next cycle of chemotherapy and chemotherapy cycle XELOX regimen for 3,4 cycle.27 patients received XELOX scheme chemotherapy for 4 cycles. Results：The median progress free survival （PFS）of chemoradiotherapy group was 7.11 months while the chemother-apy group was 5.13 months.There were statistical significance between the two groups（P 〈0.05）.The 1 year surviv-al rate was 60 % in the concurrent chemoradiotherapy group and 5 1 % in the chemotherapy group.There were no statistical significance .The objective response rates of tumor （ORR）were 67.8% and 40.7%,respeccivelly（P 〈0.05）.The KPS score of the two groups had no statistical significance prior and post treatment （P 〉0.05）.Conclu-sion：The chemoradiotherapy can improve the efficacy of locally advanced gastric carcinoma patients （Ⅱ -Ⅲc ）with-out operation.