Eag1蛋白在卵巢肿瘤组织中的表达及意义

Expression and significance of ether à go-go 1 protein in human ovarian tumor

目的:研究Eag1蛋白在卵巢肿瘤组织中的表达,探讨其与卵巢癌发生、发展的相关性。方法:采用免疫组化的方法,检测2008年1月-2010年12月厦门大学附属东南医院妇产科收治的卵巢癌39例、交界性卵巢肿瘤10例、良性卵巢肿瘤10例标本中Eag1蛋白的表达水平。结果:39例卵巢癌标本Eag1均阳性表达,并恶性程度与表达状态呈正相关;10例交界性卵巢肿瘤标本Eag1强表达2例,弱表达6例,阴性2例;10例良性卵巢肿瘤标本1例弱阳性表达,9例阴性。结论:Eag1蛋白与卵巢癌发生、发展及疾病的预后密切相关性。

Objective：To detect the protein expression of Eag1 in human ovarian tumor tissue,and study the corre-lation with human ovarian cancer occurrence,development.Methods：Immunohistochemical method was used to test the Eag1 protein expression level of 39 cases of ovarian cancer,10 cases of border ovarian tumor,10 cases of benign o-varian tumor.Results：All 39 cases of ovarian cancer specimens were positively expressed,and positively associated with malignant degree.2 cases strong expression,6 cases weak expression and 2 cases negative in 10 cases of border ovarian tumor,9 cases negative and 1 case weak expression in 10 cases of benign ovarian tumor.Conclusion：The ex-pression of Eag1 has significant correlation with human ovarian cancer occurrence,development and prognosis.