远志及其炮制品解酒作用研究

Study on the Anti-alcoholism Effect of Polygala tenuifolia Willd.and its Processed Products

目的:研究远志及其炮制品(甘草炙和蜜炙)对急性酒精中毒小鼠的防醉解酒作用。方法:ICR小鼠给药30min后,灌胃给予52°白酒诱导建立小鼠急性酒精中毒模型,并对小鼠共济失调发生潜伏期、攀附时间及醉酒率进行观察,并检测肝组织乙醇脱氢酶(ADH)的活性。结果:远志及其炮制品水提液可显著改善急性酒精中毒小鼠的醉酒情况,其中甘草炙远志高剂量组可显著延长共济失调发生潜伏期,延长小鼠攀附时间,降低醉酒率,并提高肝组织乙醇脱氢酶(ADH)活性。结论:甘草炙远志高剂量组具有显著的解酒效果。

Objective：To study the anti alcoholism effect of Polygala tenuifolia Willd. and its processed products which were processed by glycyrrhizae and refined honey. Methods：Water extractions were administrated to ICR mice,30 minutes later,acute alco holism model was established by alcohol gavage （52%U/U）. Then we observed the ataxia incubation period,cling time and the rate of alcoholism;And the serum Alcohol dehydrogenase （ADH） activity was detected. Results： The water extraction of Polygala tenuifolia Willd. and its processed products could improve the hangover significantly. Especially the high dose of Polygala tenuifolia processed by glycyrrhizae could apparently extend the ataxia incubation period and the cling time, reduce the rate of alcoholism and enhance ADH activity. Conclusion ： The high close of Polygala tenuifolia processed by glycyrrhizae had a significant effect of antialcoholism.