妊娠期糖尿病患者血浆D-二聚体和国际标准化比值水平分析

Analysis of Levels of Plasma D-dimer and INR in Gestational Diabetes Mellitus

目的:观察妊娠期糖尿病(GDM)患者血浆D-二聚体和国际标准化比值(INR)水平变化。方法:随机选取孕34周以上GDM患者50例(GDM组),孕34周以上正常妇女52例(对照组),分别用免疫比浊法和凝固法检测两组孕妇血浆D-二聚体浓度和INR[通过凝血酶原时间(PT)计算],对比分析组间差异。结果:GDM组患者D-二聚体浓度显著高于对照组(2.54±1.83vs 1.83±0.95,P<0.05);GDM组INR虽低于对照组,但差异无统计学意义(0.99±0.20vs 1.02±0.37,P>0.05)。结论:GDM患者的血液凝固性和纤溶代偿功能均高于正常孕妇,需防范其血栓并发症及产后出血。

Objective： To observe the changes of plasma D-dimer and international normalized ratio （INR） level in gestational diabetes mellitus （GDM） patients. Method： 50 cases of gestational diabetes over 34 gestational weeks were randomly selected into GDM group;52 normal pregnant women over 34 gestational weeks as the control group, both groups were tested for maternal plasma D-dimer and INR levels and were comparatived for analysis. Results： GDM group D-dimer was higher than the control group （2.54±1. 83 vs 1.83 ± 0. 95, P〈 0. 05）; GDM group INR lower than the control group, but the difference was not statistically significant （0.99±0.20 vs 1.02± 0.37, P〉0.05）. Conclusion： GDM patients blood coagulation and fibrinolysis compensatory function were higher than normal pregnant women, and therefore need to prevent thrombotic complications and postpartum hemorrhage.