天灸散中白芥子的不同粉碎方法与临床疗效关系的研究

Study of the relationship between difference comminution methods and clinical effect of Semen brassicae in Tianjiu powder

目的研究天灸散中白芥子不同粉碎方法与临床疗效的关系。方法分别采用干法粉碎和湿法粉碎两种方法粉碎白芥子,后与甘遂、细辛、延胡索、生姜汁制成天灸药泥。进行皮肤刺激性对比试验和起效时间的对比及治疗过敏性鼻炎临床疗效观察。结果采用湿法粉碎白芥子方法制得的软泥在皮肤刺激性对比试验反应积分为1h(2.45±0.04)分、24h(1.82±0.03)分、48h(1.34±0.02)分、72h(0.78±0.03)分;10人皮肤起效时间均差为(10.6±2.90)min,有较强的发热感和辣感;临床有效率为91.25%,各方面都优于采用干法粉碎白芥子方法所制得的软泥的各值(P<0.05)。结论湿法粉碎白芥子是一种可行的方法,在制备天灸药泥中值得进一步研究。

Objective To study the relationship between difference comminution methods and clinical effect of Semen brassicae in Tianjiu powder.Methods Semen brassicae was respectively comminuted with dry smashing and wet smashing, then was made of medicine mud combined with Euphorbia kansui, Asarum sieboldi Mig., Corydalis ambigua Ch., and ginger juice. To observe the contrast test of skin irritation, the effect onset time, and the clinical effect on allergic rhinitis.ResultsThe reactive integrals of contrast test of skin irritation were （2.45±0.04） in 1h, （1.82±0.03） in 24h, （1.34±0.02） in 48h, and （0.78±0.03） in 72h, the average deviation of effect onset time of 20 patients was （10.6±2.90）min, with strong heat sensation and piquancy, and the clinical effective rate was 91.25% in wet smashing group, which were all better than which in dry smashing group, the differences were statistical significance（P〈0.05）.Conclusion Wet smashing of Semen brassicae is a feasible method, is worthy of further study on the preparation of Tianjiu powder.