外用重组牛碱性成纤维细胞生长因子结合中药沐足治疗糖尿病足难愈创口临床研究

Clinical research of recombinant bovine basic fibroblast growth factor for external use combined with traditional Chinese medicine foot bath in treatment of diabetic foot with badly healing wound

目的探讨外用重组牛碱性成纤维细胞生长因子结合中药沐足治疗糖尿病足难愈创口的临床疗效。方法选取2012年8月~2014年1月我院糖尿病足部溃疡患者60例,随机分为观察组和对照组,各30例。观察组给予中药沐足、l%Ag-SD霜联合重组牛碱性成纤维细胞生长因子局部外用,而对照组仅局部外用l%Ag-SD霜。观察及比较两组患者治疗后临床疗效、创面愈合时间、住院时间及不良反应情况。结果观察组患者总有效率明显高于对照组,创面愈合时间和住院时间明显短于对照组（P〈0.05）,且两组均未见不良反应。结论外用重组牛碱性成纤维细胞生长因子联合中药沐足治疗糖尿病足难愈创口患者疗效安全、有效,能促进创面愈合,缩短住院时间。

Objective To investigate the clinical efficacy of recombinant bovine basic fibroblast growth factor for external use combined with traditional Chinese medicine foot bath in treatment of diabetic foot with badly healing wound.Methods 60 patients of diabetic foot ulcer from August 2012 to January 2014 in our hospital were chosed and randomly divided into the observation group and control group,each group in 30 cases.The observation group was given traditional Chinese medicine foot bath,l% Ag-SD cream combined with recombinant bovine basic fibroblast growth factor for external use,while the control group was given only l% Ag-SD cream for external use.The clinical efficacy,wound healing time,hospitalization time and adverse reactions of patients in two groups after treatment were observed and compared.Results The total effective rate of patients in the observation group was significantly better than that in the control group,wound healing time and hospitalization time were significantly shorter than those in the control group （P〈0.05）,and no adverse reactions happened in the two groups.ConclusionRecombinant bovine basic fibroblast growth factor for external use combined with traditional Chinese medicine foot bath in treatment of diabetic foot with badly healing wound is safe and effective,can promote the wound healing,shorten the hospitalization time.