大剂量丙种球蛋白治疗新生儿ABO溶血病的疗效观察

Observe the therapeutic effect of large dose of gamma globulin in treatment of neonatal ABO hemolytic disease

目的观察大剂量丙种球蛋白（IVIG）治疗新生儿ABO溶血病的临床疗效。方法临床纳入97例诊断为ABO溶血病的新生儿,根据患者治疗方案的不同分为大剂量IVIG组、低剂量IVIG组以及对照组。大剂量IVIG组每日给予IVIG 1g/kg,低剂量IVIG组每日给予IVIG 0.4g/kg,对照组未使用IVIG治疗。观察新生儿出生后1、2、3~5d入院治疗后的血清总胆红素（TBIL）水平变化。结果新生儿出生后1、2、3~5d入院治疗24、48h,大剂量IVIG组TBIL水平显著低于低剂量IVIG组以及对照组,差异有统计学意义（P〈0.05）。结论早期给予大剂量IVIG治疗新生儿ABO溶血病,能够有效减低患儿血清TBIl水平,减少黄疸以及相关后遗症的发生。

Objective To observe the effect of large dose of gamma globulin （IVIG） clinical efficacy in the treatment of neonatal ABO hemolytic disease.Methods97 patients with diagnosis of ABO hemolytic disease of the newborn were selected in our hospital, according to the treatment of patients , they were divided into IVIG of high dose group, low dose IVIG group and control group. Large doses of IVIG group were given IVIG 1g/kg, low dose IVIG group received daily IVIG 0.4g/kg, the control group did not use IVIG treatment. The serum total bilirubin （TBIL） level change of neonatal 1、2、3~5d admitted to the hospital after birth were observed.Results After the birth of 1, 2, 3-5d, 24h, 48h in hospital treatment, TBIL level of high dose IVIG group was significantly lower than the low dose IVIG group and the control group, the difference was significant （P〈0.05）.Conclusion Early high-dose IVIG treatment of ABO hemolytic disease of the newborn, can effectively reduce the level of serum TBIl in children, reduce the incidence of jaundice and related sequelae.