潮气量机械通气不同情况下对肺损伤的影响及有效性护理对策

Effect and effective nursing countermeasure of tidal volume mechanical ventilation on lung injury at different condition

目的分析潮气量机械通气在不同的情况之下对于肺损伤所造成的影响,探讨有效的护理对策。方法把120例患者随机分成对照组、小潮气量机械通气组(通气A组)及大潮气量机械通气组(通气B组),三组各40例,通气A组与通气B组通气的时间皆为4h。检测患者肺组织的总蛋白、白细胞的计数、肿瘤的坏死因子α蛋白与m RNA含量以及中性粒细胞细胞髓的过氧化物酶(MPO)含量,制定相应的护理对策。结果和对照组相比较,通气B组的肺组织的总蛋白、白细胞的计数、肿瘤的坏死因子α蛋白与mRNA含量以及MPO含量皆有明显增加,差异有统计学意义(P<0.05);而通气A组上述指标变化不明显,差异无统计学意义(P>0.05)。结论大潮气量机械通气会造成呼吸机致使肺损伤,在临床要要加强对于机械通气的护理防护,制定有效的护理对策,采取综合护理干预的方法能够有效的促进患者早日康复。

Objective To analyze the effect of tidal volume mechanical ventilation on lung injury at different condition, to study the effective nursing countermeasure. Methods120 patients were randomly divided into control group, low tidal volume mechanical ventilation group（ventilation A group）, and large tidal volume mechanical ventilation group（ventilation B group）, with 40 cases in each group and with the ventilation time of 4h in ventilation A group and ventilation B group. To detect the total protein, leukocyte count, tumor necrosis factor α, content of Mrna, content of myeloperoxidase in neutrophil （MPO）of patients’ lung tissue, to establish corresponding nursing countermeasure.Results The total protein, leukocyte count, tumor necrosis factor α, content of mRNA, content of MPO of patients＇ lung tissue in ventilation B group were obviously increased than which in control group, the difference were statistical significance（P〈0.05）, while which in ventilation A group didn＇t had obvious change than which in control group, there was no statistical significance（P〉0.05）.Conclusion Large tidal volume mechanical ventilation, which will cause lung injury, should be strengthened on nursing protection to make effective nursing countermeasure and to adopt comprehensive nursing intervention which could effective promote patients＇ rehabilitation early.