检测降钙素原对PICU感染性疾病患儿预后的预测价值

The predictive value of PCT detection for prognosis of children with infectious diseases in PICU

目的探讨降钙素原对PICU感染性疾病患者预后的预测价值。方法回顾性分析236例感染性危重病患儿的临床资料,分析患者降钙素原水平与预后的关系。结果 236例患儿治愈215例,占87.4%,21例患儿死亡,占8.9%。死亡组≥10ng/m L的比例显著高于治愈组(P<0.01)。Spearman相关分析结果显示PCT水平与APACHEⅡ呈正相关(r=0.731,P<0.01)。以≥10ng/m L为界值的约登指数最大,说明以≥10ng/m L的预测价值相对较高。结论 PICU感染性疾病患儿PCT水平与入住PICU时APACHEⅡ评分呈显著正相关,死亡患儿PCT水平≥10ng/m L的比例显著高于治愈患儿,以≥10ng/m L为界值对患儿预后的预测价值相对较高。

Objective To discuss predictive value of PCT detection for prognosis of children with infectious diseases in PICU. Methods Clinical data of 236 cases with infectious diseases in PICU were retrospectively analyzed. Relationship of PCT leves and prognosis was analyzed. Results Of 236 cases, 215 cases cured, accounting for 87.4%, and 21 cases were death, accounting for 8.9%. Proportion of PCT ≥ 10ng/mL of death group was higher than cure group（P〈0.01）. Spearman results showed PCT was positive correlation with APACHEⅡ（r=0.731,P〈0.01）. Cutoff value of ≥10 ng/mL was maximum Youden index, which predictive value was relatively high. Conclusion PCT of children with infectious diseases in PICU is positive correlation with APACHEⅡ, proportion of PCT≥10ng/mL of death group is higher than cure group, and ≥10ng/mL predictive value is relatively high.