左旋布比卡因在婴儿唇裂修复术中的应用研究

The applied research of levobupivacaine on the repair of cleft lip in infant

目的研究左旋布比卡因局部浸润麻醉在婴儿唇裂修复术中的镇痛作用及安全性。方法将90例拟行先天性单侧唇裂修复术的3个月~1岁龄的患儿随机平均分为三组,分别为对照组L组,实验组LB1组和LB2组,分别使用0.5%利多卡因、0.15%和0.25%左旋布比卡因,局麻药中均含有肾上腺素。患儿全麻后予相应局麻药术区局麻,术毕记录下三组患儿术后1h、2h的疼痛评分。结果三组患儿围术期均未发生严重不良反应,LB1组和LB2组患儿术后1h和2h的疼痛评分均明显低于L组患儿的疼痛评分（P〈0.05）,而LB1组和LB2组在术后1h和2h的疼痛评分差异无统计学意义（P〉0.05）。结论与0.5%利多卡因相比,0.15%左旋布比卡因局部浸润麻醉能安全有效地应用于婴儿先天性唇裂修复术,而且术后镇痛效果更佳。

Objective To study the analgesic effect and safety of levobupivacaine which used to local infiltration anesthesia in cleft lip repair in infant. Methods 90 infants patients,which of 3 months to 1 year old,equally devided into 3 groups at random,they are L group,LB1 group and LB2 group,the three groups respectively used 0.5% lidocaine,0.15% levobupivacaine,and 0.25% levobupivacaine to local infiltration anesthesia.and all the local anesthetics contained 0.0005% epinephrine.Then,first of all,we performed general anesthesia for the infants patients,after that,the surgeons injected the appointed local anesthetics into the operative site and began the operation. Then,we recorded the pain scores of 1 hour and 2 hours after operation. Results All the patients of the three groups didn＇t happen any serious adverse reaction in the perioperative period.The pain scores of 1 hour and 2 hours post-operative of LB1 group,as well as those of LB2 group,had been both obviously lower than those of L group（P〈0.05）. However,the difference of the pain scores of LB1 group and LB2 group had no statistical significance（P 〉 0.05）. Conclusion The 0.15%levobupivacaine,which used to local infiltration anesthesia,could safely and effectively used in the congenital cleft lip repair in infant, moreover,the effect of postoperative analgesia of levobupivacaine were better than 0.5%lidocaine.