降钙素原和超敏C反应蛋白检测在慢性阻塞性肺疾病急性加重期的意义

Detection significance of serum procalcitonin and high-sensitivity C-reactive protein in acute exacerbation stage of chronic obstructive pulmonary disease

目的探讨降钙素原和超敏C反应蛋白在慢性阻塞性肺疾病急性加重期中的检测效果及其意义。方法对来我院诊治的40例慢性阻塞性肺疾病急性加重期患者设为实验组,取40例非急性加重期慢性阻塞性肺疾病患者为对照组,比较两组PCT及hs-CRP水平。结果实验组治疗前PCT指标为(3.32±0.81)ng/m L、hs-CRP指标为(22.36±5.03)mg/L、WBC指标为(10.31±1.56)×109/L,均高于对照组(P<0.05);实验组PCT、hs-CRP阳性诊断率分别为67.5%和60%,均高于对照组(P<0.05)。结论慢性阻塞性肺疾病急性加重期采用PCT和hs-CRP联合诊断具有重要的临床价值,值得推广使用。

Objective To study the detection effect and significance serum procalcitonin（PCT）and high-sensitivity C-reactive protein（hs-CRP）in acute exacerbation stage of chronic obstructive pulmonary disease. Methods 40 cases with chronic obstructive pulmonary disease in acute exacerbation stage who were treated in our hospital were selected as experimental group,while 40 cases in non-acute exacerbation stage were selected as control group.To compare the level of PCT and hs-CRP between the two groups. Results PCT（3.32±0.81）ng/mL,hs-CRP（22.36±5.03）mg/L,WBC（10.31±1.56）×109/L before treatment in experimental group were higher than which in control group,the differences all had statistical significance（P〈0.05）.The positive diagnostic rate of PCT（67.5%）and hs-CRP（60%）in experimental group were higher than which in control group,the differences all had statistical significance（P〈0.05）. Conclusion Detection of PCT combined hs-CRP in acute exacerbation stage of chronic obstructive pulmonary disease has significant clinical value and is worthy of popularization and application.