丙种球蛋白联合阿司匹林治疗小儿川崎病的临床疗效观察

Clinical observation of gamma globulin and aspirin therapy in children with Kawasaki disease

目的：研究丙种球蛋白联合阿司匹林对小儿川崎病的临床治疗效果及安全性，为临床治疗川崎病提供参考和借鉴。方法选择2012年1月~2014年7月我院收治的46例小儿川崎病患儿作为临床研究对象，随机分为两组。对照组患者23例，单纯使用阿司匹林治疗；实验组患者23例给予阿司匹林联合丙种球蛋白治疗，对比观察两组患儿的治疗效果和症状改善时间。结果实验组患儿发热时间短、黏膜充血时间更短、颈淋巴结消散快，患儿手足肿胀时间短，与对照组比较差异有统计学意义（P ＜0.05）；对照组患儿发生冠状动脉扩张比例较高，与实验组比较差异有统计学意义（P ＜0.05）。结论使用丙种球蛋白联合阿司匹林对小儿川崎病治疗的效果较好，有助于患儿早期康复，降低冠状动脉扩张率，值得应用。

Objective To clinical efficacy and safety of gamma globulin combined aspirin on children with Kawasaki disease,provide reference for the clinical treatment of Kawasaki disease. Methods 46 cases of children with Kawasaki disease in our hospital from January 2012 to July 2014 were selected as a clinical study,were randomly divided into two groups.23 patients in the control group only received aspirin therapy;the experimental group with 23 patients further received gamma globulin therapy,treatment effects and symptoms time between the two groups were compared. Results Children with a short fever time in the experimental group,mucosal congestion was shorter,neck lymph nodes dissipate was quicker,the time of children with hand,foot swelling was shorter,compared with the control group with significant difference（P 〈 0.05）;the children in the control group occurred a higher proportion of coronary dilatation,with significant differences between the two groups（P 〈 0.05）,the difference was statistically significant. Conclusion The use of gamma globulin and aspirin therapy in children with Kawasaki disease is better,help children with early rehabilitation,reduce the rate of coronary artery,and it is worthy of applications.