盐酸氨溴索联合布地奈德治疗重症肺炎的疗效研究

The study on effect of ambroxol hydrochloride combined with budesonide in the treatment of severe pneumonia

目的：分析盐酸氨溴索联合布地奈德治疗重症肺炎的临床疗效。方法分析我院自2013年1月～2014年6月收治的164例重症肺炎的患者，164例患者随机分为治疗组（84例）与对照组（80例）。两组均给予以机械通气、化痰、解痉、抗感染及营养支持等常规治疗。治疗组在对照组的基础上加用盐酸氨溴索联合布地奈德雾化吸入。比较两组临床疗效，临床症状和血气分析。结果对照组与治疗组临床总有效率分别为82.50%（66/80），95.24%（80/84），两组比较（x2=9.057，P ＜0.05）；FEV1、FEV1/FVC、PaO2、PaCO2水平比较，两组治疗后与同组治疗前比较，差异有统计学意义（P ＜0.05），两组治疗后比较，差异有统计学意义（P ＜0.05）。结论盐酸氨溴索联合布地奈德治疗重症肺炎，可以提高临床疗效，改善患者血气水平，具有临床应用的价值。

Objective To analyze the clinical curative effect of ambroxol hydrochloride combined with budesonide in the treatment of severe pneumonia. Methods 164 cases of severe pneumonia in our hospital from 2013 January to 2014 June were analyzed and randomly divided into the treatment group（84 cases）and the control group（80 cases）. The patients of two groups were given routine treatment such as mechanical ventilation,expectorant,antispasmodic,a nti infection and nutrition support.The treatment group was given ambroxol hydrochloride combined with budesonide inhalation based on the treatment of control group.The clinical effects,the clinical symptoms and blood gas analysis of the two groups were compared with each other. Results The total clinical effective rates of the control group and the treatment group were 82.50%（66/80）,95.24%（80/84）,There was statistically significant（x2=9.057,P 〈 0.05）. A comparison of FEV1,FEV1/FVC,PaO2, PaCO2 level,there were statistically significant compared with the same group before treatment（P 〈 0.05）;there was statistically significant between two groups after treatment（P 〈 0.05）. Conclusion Ambroxol hydrochloride combined with budesonide in the treatment of severe pneumonia,can improve the clinical efficacy and blood levels of patients.It is worthy of clinical application.