新辅助化疗联合腹腔镜手术在结直肠癌治疗中的疗效分析

Analysis of effect of neoadjuvant chemotherapy combined with laparoscopic operation in the treatment of colorectal cancer

目的：探讨新辅助化疗联合腹腔镜手术治疗结直肠癌的临床效果。方法选取2010年1月~2014年1月我院治疗的结直肠癌患者60例，随机分为两组，每组30例。观察组患者采用新辅助化疗联合腹腔镜手术治疗，对照组患者采用传统开腹手术治疗。比较两组患者术后肛门排气时间、住院时间、伤口感染、并发症，及患者生存时间、生存质量的改善情况。结果观察组患者术后肛门排气时间和住院时间明显短于对照组，伤口感染率和并发症发生率明显低于对照组（P ＜0.05）。观察组患者平均生存时间明显长于对照组，生存质量改善率明显高于对照组（P ＜0.05）。结论新辅助化疗联合腹腔镜手术治疗结直肠癌疗效确切，可延长患者术后生存时间，提高生存质量，值得临床推广应用。

Objective To explore the clinical effect of neoadjuvant chemotherapy combined with laparoscopic operation in the treatment of colorectal cancer. Methods 60 patients with colorectal cancer from 2010 January to 2014 January in our hospital were randomly divided into two groups, 30 cases in each group. The observation group were treated by neoadjuvant chemotherapy combined with laparoscopic operation treatment, the control group were treated by traditional open operation treatment. The postoperative anal exhaust time, hospitalization time, wound infection, complications, survival time and quality of life of patients in the two groups were observed and compared. Results The postoperative anal exhaust time and hospitalization time of patients in the observation group were significantly shorter than those in the control group, and the incidence of wound infection and complications were significantly lower than those in the control group（P 〈 0.05）. The mean survival time of patients in the observation group was significantly longer than that in the control group, and the improvement rate of quality of life was significantly higher than that in the control group（P 〈 0.05）. Conclusion Neoadjuvant chemotherapy combined with laparoscopic operation in the treatment of colorectal cancer has significant effect, can prolong postoperative survival time of patients, improve quality of life of patients,and it is worthy of clinical application.