皮肤原位再生复原技术防治瘢痕的临床疗效观察

Clinical Efficacy Observation of MEBT/MEBO in the Prevention and Treatment of Scar

目的探讨美宝疤痕软膏（以下简称疤痕软膏）防治烧伤、创伤、溃疡等创面愈后瘢痕及治疗陈旧性瘢痕的效果。方法预防瘢痕：将疤痕软膏均匀涂抹于烧伤创面愈合1周的皮肤上,厚约0.5 mm,30 d内每日涂抹3~4次,禁止按摩;30 d后每日涂抹2次,加压包扎。治疗陈旧性瘢痕（12个月以上的成熟瘢痕）：将疤痕软膏均匀涂抹于陈旧性瘢痕皮肤上,厚约1.0 mm,用手掌加压按摩15 min后加压包扎,每日2次,3个月为1个疗程。结果 134例患者中,预防瘢痕者67例（104处瘢痕）,其中显效69处（66.4%）,有效30处（28.8%）,无效5处（4.8%）;陈旧性瘢痕治疗者67例（104处瘢痕）,其中显效70处（67.3%）,有效32处（30.8%）,无效2处（1.9%）。结论疤痕软膏能改善血液循环,具有软化皮肤、调控上皮细胞与成纤维细胞比例、缓解疼痛瘙痒、平复瘢痕等作用,其安全有效,副作用小,值得推广应用。

Objective To explore the clinical efficacies of MEBO Scar Ointment （Scar Ointment for short） in preventing scar formation and treating old scars resulting from healed burns, traumas, ulcers and other wounds. Methods Scar prevention： smear Scar Ointment at a thickness of about 0. 5 mm onto the burned skin newly healed for one week, change the Ointment 3 -4 times every day for 30 days with no massage; 30 days later change it 2 times every day and band- age the skin with pressure. Treatment of old scars （mature scars formed for more than 12 months） ： smear Scar Ointment on- to the scar at an even thickness of 1.0 mm, massage for 15 min with palm pressure followed by pressure bandage, 2 times every day, 3 months for a treatment course. Results In the enrolled 134 patients, 67 patients （ 104 scars） were to prevent scar formation and 67 patients （ 104 scars） were to treat old scars. Among the former 104 scars, 69 scars （66. 4% ） showed obvious effective, 30 （ 28. 8% ） were effective and 5 （4. 8% ） were ineffective while among the later 104 old scars, 70 （67.0%） scars showed obvious effective, 32 （31.0%） were effective and 2 （1.9%） were ineffective. Conclusion Scar Ointment has the functions of improving blood circulation, softening skin, regulating the ratio of epithelial cells and fibro- blasts, relieving pain and itch, removing scars and etc. It is effective and safe with little adverse effects, deserving to be popularized for application.